product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
GM 6001
catalog :
2983/10
quantity :
10 mg
price :
376 USD
more info or order :
citations: 10
Reference
Kim H, Yin W, Jin Y, Panza P, Gunawan F, Grohmann B, et al. Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease. Nat Commun. 2018;9:4600 pubmed publisher
Luo F, Tran A, Xin L, Sanapala C, Lang B, Silver J, et al. Modulation of proteoglycan receptor PTPσ enhances MMP-2 activity to promote recovery from multiple sclerosis. Nat Commun. 2018;9:4126 pubmed publisher
Lahey K, Ronaghan N, Shang J, Dion S, Desilets A, Leduc R, et al. Signaling pathways induced by serine proteases to increase intestinal epithelial barrier function. PLoS ONE. 2017;12:e0180259 pubmed publisher
Sun C, Feng S, Cao Z, Bei J, Chen Q, Zhao W, et al. Up-Regulated Expression of Matrix Metalloproteinases in Endothelial Cells Mediates Platelet Microvesicle-Induced Angiogenesis. Cell Physiol Biochem. 2017;41:2319-2332 pubmed publisher
Conant K, Daniele S, Bozzelli P, Abdi T, Edwards A, Szklarczyk A, et al. Matrix metalloproteinase activity stimulates N-cadherin shedding and the soluble N-cadherin ectodomain promotes classical microglial activation. J Neuroinflammation. 2017;14:56 pubmed publisher
Schumacher M, Hedl M, Abraham C, Bernard J, Lozano P, Hsieh J, et al. ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation. Cell Death Dis. 2017;8:e2622 pubmed publisher
Greene J, Portillo J, Lopez Corcino Y, Subauste C. CD40-TRAF Signaling Upregulates CX3CL1 and TNF-α in Human Aortic Endothelial Cells but Not in Retinal Endothelial Cells. PLoS ONE. 2015;10:e0144133 pubmed publisher
Son S, Kang S, Choi H, Mook Jung I. Statins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway. Mol Neurodegener. 2015;10:56 pubmed publisher
Leung W, Vong Q, Lin W, Bouck D, Wendt S, Sullivan E, et al. PRL-3 mediates the protein maturation of ULBP2 by regulating the tyrosine phosphorylation of HSP60. J Immunol. 2015;194:2930-41 pubmed publisher
Le Bras G, Taylor C, Koumangoye R, Revetta F, Loomans H, Andl C. TGF? loss activates ADAMTS-1-mediated EGF-dependent invasion in a model of esophageal cell invasion. Exp Cell Res. 2015;330:29-42 pubmed publisher
product information
brand :
Tocris
master code :
2983
SKU :
2983/10
product name :
GM 6001
description :
Broad spectrum MMP inhibitor
target :
Synthetic Metalloprotease Inhibitors
category :
Small Molecules
unit sizes :
10 mg
purity :
95%
observed molecular weight :
388.46
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
GM 6001 is a broad spectrum MMP inhibitor. Reduces infarct volume following middle cerebral artery occlusion in an ischemic mouse model. Also inhibits human skin fibroblast collagenase (Ki = 0.4 nM).
extended description :
Broad spectrum MMP inhibitor
chemical name text :
(2R)-N4-Hydroxy-N1-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)butanediamide
formula :
C 20 H 28 N 4 O 4
formula text :
C20H28N4O4
cas num :
142880-36-2
USD :
376 USD
product details :
Broad spectrum MMP inhibitor
alt names :
Galardin, Ilomastat
storage :
Store at -20°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK