BIBR 1532 | Tocris Bioscience 2981/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BIBR 1532

catalog :

2981/10

quantity :

10 mg (also 50 mg)

price :

271 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Mahfouz N, Tahtouh R, Alaaeddine N, El Hajj J, Sarkis R, Hachem R, et al. Gastrointestinal cancer cells treatment with bevacizumab activates a VEGF autoregulatory mechanism involving telomerase catalytic subunit hTERT via PI3K-AKT, HIF-1? and VEGF receptors. PLoS ONE. 2017;12:e0179202 pubmed publisher
Beyer A, Freed J, Durand M, Riedel M, Ait Aissa K, Green P, et al. Critical Role for Telomerase in the Mechanism of Flow-Mediated Dilation in the Human Microcirculation. Circ Res. 2016;118:856-66 pubmed publisher
Farnung B, Brun C, Arora R, Lorenzi L, Azzalin C. Telomerase efficiently elongates highly transcribing telomeres in human cancer cells. PLoS ONE. 2012;7:e35714 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2981

SKU :

2981/10

product name :

BIBR 1532

description :

Selective telomerase inhibitor

target :

Telomerase Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at RT

observed molecular weight :

331.36

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

BIBR 1532 is a selective telomerase inhibitor (IC50 values are 93, 100000 and 100000 nM for human telomerase, human RNA polymerase I and human RNA polymerase II + III respectively). Causes telomere shortening in exponentially growing NCI-H460 lung carcinoma cells and eventual growth arrest.

product keywords :

Selective telomerase inhibitors inhibits BIBR1532 Telomerase DNA, RNA and Protein Synthesis 2981,

extended description :

Selective telomerase inhibitor

chemical name text :

2-[[(2E)-3-(2-Naphthalenyl)-1-oxo-2-butenyl1-yl]amino]benzoic acid

formula :

C21H17NO3

formula text :

C21H17NO3

cas num :

321674-73-1

USD :

268

USD 2025 :

271 USD

product details :

Selective telomerase inhibitor

more info or order :

Tocris Bioscience product webpage