GW 843682X | Tocris Bioscience 2977/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GW 843682X

catalog :

2977/1

quantity :

1 mg (also 10 mg, 50 mg)

price :

115 USD

more info or order :

Tocris Bioscience product webpage

citations: 9

Reference
O Connor A, Maffini S, Rainey M, Kaczmarczyk A, Gaboriau D, Musacchio A, et al. Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpoint. Biol Open. 2015;5:11-9 pubmed publisher
Hu H, Liu Y, Zhou Q, Siegel S, Li Z. The Centriole Cartwheel Protein SAS-6 in Trypanosoma brucei Is Required for Probasal Body Biogenesis and Flagellum Assembly. Eukaryot Cell. 2015;14:898-907 pubmed publisher
Barton O, Naumann S, Diemer Biehs R, KÃ¼nzel J, Steinlage M, Conrad S, et al. Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1. J Cell Biol. 2014;206:877-94 pubmed publisher
Hu J, Wang G, Liu X, Zhou L, Jiang M, Yang L. Polo-like kinase 1 (PLK1) is involved in toll-like receptor (TLR)-mediated TNF-α production in monocytic THP-1 cells. PLoS ONE. 2013;8:e78832 pubmed publisher
Waxman E, Giasson B. Characterization of kinases involved in the phosphorylation of aggregated ?-synuclein. J Neurosci Res. 2011;89:231-47 pubmed publisher
Manchado E, Guillamot M, de Carcer G, Eguren M, Trickey M, Garcia Higuera I, et al. Targeting mitotic exit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55?,? phosphatase. Cancer Cell. 2010;18:641-54 pubmed publisher
Pal D, Wu D, Haruta A, Matsumura F, Wei Q. Role of a novel coiled-coil domain-containing protein CCDC69 in regulating central spindle assembly. Cell Cycle. 2010;9:4117-29 pubmed
Colnaghi R, Wheatley S. Liaisons between survivin and Plk1 during cell division and cell death. J Biol Chem. 2010;285:22592-604 pubmed publisher
Scutt P, Chu M, Sloane D, Cherry M, Bignell C, Williams D, et al. Discovery and exploitation of inhibitor-resistant aurora and polo kinase mutants for the analysis of mitotic networks. J Biol Chem. 2009;284:15880-93 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2977

SKU :

2977/1

product name :

GW 843682X

description :

Selective inhibitor of PLK1 and PLK3

target :

Polo-like Kinase Inhibitors

unit size :

1 mg (also 10 mg, 50 mg)

category :

Small Molecules

purity :

98%

storage :

Desiccate at +4°C

observed molecular weight :

477.46

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

GW 843682X is a selective inhibitor of polo-like kinase 1 (PLK1) and polo-like kinase 3 (PLK3) (IC50 values are 2.2 and 9.1 nM respectively). Displays 100-fold selectivity over ~30 other kinases tested including cdk1 and cdk2. Inhibits proliferation of most tumor cells in vitro and is selective over normal diploid fibroblasts.

product keywords :

Selective inhibitors inhibits PLK1 PLK3 Mitosis Polo-like Kinases GW843682X GlaxoSmithKline GSK Polo-like Kinase Mitosis 2977,

extended description :

Selective inhibitor of PLK1 and PLK3

chemical name text :

5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(trifluoromethyl)phenyl]methoxy]-2-thiophenecarboxamide

formula :

C22H18F3N3O4S

formula text :

C22H18F3N3O4S

cas num :

660868-91-7

USD :

127

USD 2025 :

115 USD

product details :

Selective inhibitor of PLK1 and PLK3

more info or order :

Tocris Bioscience product webpage