A 803467 | Tocris Bioscience 2976 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

A 803467

catalog :

2976

quantity :

10 mg (also 50 mg)

price :

136 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Wu X, Cao D, Zhang X, Jiang B, Zhao L, Qian B, et al. CXCL13/CXCR5 enhances sodium channel Nav1.8 current density via p38 MAP kinase in primary sensory neurons following inflammatory pain. Sci Rep. 2016;6:34836 pubmed publisher
Mascanfroni I, Takenaka M, Yeste A, Patel B, Wu Y, Kenison J, et al. Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-Î±. Nat Med. 2015;21:638-46 pubmed publisher
Curtright A, Rosser M, Goh S, Keown B, Wagner E, Sharifi J, et al. Modeling nociception in zebrafish: a way forward for unbiased analgesic discovery. PLoS ONE. 2015;10:e0116766 pubmed publisher
Liu X, Yang J, Fang D, Cai J, Wan Y, Xing G. Functional upregulation of nav1.8 sodium channels on the membrane of dorsal root Ganglia neurons contributes to the development of cancer-induced bone pain. PLoS ONE. 2014;9:e114623 pubmed publisher
Stone A, Kim J, Yamauchi K, Ruiz Velasco V, Kaufman M. Attenuation of autonomic reflexes by A803467 may not be solely caused by blockade of NaV 1.8 channels. Neurosci Lett. 2013;543:177-82 pubmed publisher
Bladen C, Zamponi G. Common mechanisms of drug interactions with sodium and T-type calcium channels. Mol Pharmacol. 2012;82:481-7 pubmed publisher
Schuelert N, McDougall J. Involvement of Nav 1.8 sodium ion channels in the transduction of mechanical pain in a rodent model of osteoarthritis. Arthritis Res Ther. 2012;14:R5 pubmed publisher

product information

brand :

Tocris

master code :

2976

SKU :

2976/10

product name :

A 803467

description :

Selective NaV1.8 channel blocker

target :

Voltage-gated Sodium Channel Blockers

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

357.79

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective blocker of NaV1.8 channels (IC50 values are 8, 2450, 6740, 7340 and 7380 nM for hNaV1.8, hNaV1.3, hNaV1.7, hNaV1.5 and hNaV1.2 channels respectively). Shows no significant activity against TRPV1, P2X2/3, CaV2.2 and KCNQ2/3 channels. Antinociceptive; potently attenuates mechanical allodynia in two models of neuropathic pain following i.p. administration.

catalog number base :

2976

product keywords :

Selective NaV18 blockers Sodium Channels voltage-gated voltage-dependent Na+ A803467 Voltage-gated Sodium Channels 2976,

extended description :

Selective NaV1.8 channel blocker

chemical name text :

5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furancarboxamide

formula :

C 19 H 16 ClNO 4

formula text :

C19H16ClNO4

cas num :

944261-79-4

2020 USD :

130

2021 USD :

136 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage