product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
Doxazosin mesylate
catalog :
2964
quantity :
50 mg
price :
106 USD
more info or order :
citations: 4
Reference
Assad Kahn S, Costa S, Gholamin S, Nitta R, Dubois L, Fève M, et al. The anti-hypertensive drug prazosin inhibits glioblastoma growth via the PKCδ-dependent inhibition of the AKT pathway. EMBO Mol Med. 2016;8:511-26 pubmed publisher
DIAZ M, Jotty K, Locke J, Jones S, Valenzuela C. Moderate Alcohol Exposure during the Rat Equivalent to the Third Trimester of Human Pregnancy Alters Regulation of GABAA Receptor-Mediated Synaptic Transmission by Dopamine in the Basolateral Amygdala. Front Pediatr. 2014;2:46 pubmed publisher
Jahchan N, Dudley J, Mazur P, Flores N, Yang D, Palmerton A, et al. A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors. Cancer Discov. 2013;3:1364-77 pubmed publisher
Cilz N, Kurada L, Hu B, Lei S. Dopaminergic modulation of GABAergic transmission in the entorhinal cortex: concerted roles of α1 adrenoreceptors, inward rectifier K⁺, and T-type Ca²⁺ channels. Cereb Cortex. 2014;24:3195-208 pubmed publisher
product information
brand :
Tocris
master code :
2964
SKU :
2964/50
product name :
Doxazosin mesylate
description :
1 antagonist
target :
Adrenergic alpha-1 Receptor Antagonists
category :
Small Molecules
unit size :
50 mg
purity :
99%
observed molecular weight :
547.58
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Selective 1-adrenoceptor antagonist (pKi values are 9.0, 8.5 and 8.4 for human 1B, 1A and 1D receptors respectively). Displays antihypertensive activity.
catalog number base :
2964
product keywords :
1-adrenoceptor alpha1-adrenoceptor a1-adrenergic 1-adrenergic alpha1-adrenergic a1-adrenoceptor antagonists Receptors UK33274 UK 33274 Adrenergic Alpha-1 Receptors 2964,
extended description :
1 antagonist
chemical name text :
4-Amino-2-[4-(1,4-benzodioxan-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquinazoline methanesulfonate
formula :
C 23 H 25 N 5 O 5 .CH 3 SO 3 H
formula text :
C23H25N5O5.CH3SO3H
cas num :
77883-43-3
2020 USD :
102
2021 USD :
106 USD
alt names :
UK 33274
storage :
Desiccate at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK