MMPIP hydrochloride | Tocris Bioscience 2963 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

MMPIP hydrochloride

catalog :

2963

quantity :

1 mg (also 10 mg, 50 mg)

price :

82 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Jantas D, Lech T, Gołda S, Pilc A, Lasoń W. New evidences for a role of mGluR7 in astrocyte survival: Possible implications for neuroprotection. Neuropharmacology. 2018;141:223-237 pubmed publisher
Johansson F, Carlsson H, Rasmussen A, Yeo C, Hesslow G. Activation of a Temporal Memory in Purkinje Cells by the mGluR7 Receptor. Cell Rep. 2015;13:1741-6 pubmed publisher
Kammermeier P. Constitutive activity of metabotropic glutamate receptor 7. BMC Neurosci. 2015;16:17 pubmed publisher
Palazzo E, Marabese I, Luongo L, Boccella S, Bellini G, Giordano M, et al. Effects of a metabotropic glutamate receptor subtype 7 negative allosteric modulator in the periaqueductal grey on pain responses and rostral ventromedial medulla cell activity in rat. Mol Pain. 2013;9:44 pubmed publisher

product information

brand :

Tocris

master code :

2963

SKU :

2963/1

product name :

MMPIP hydrochloride

description :

Potent and selective negative allosteric modulator of mGlu7 receptors

target :

Group III mGluR Antagonists

category :

Small Molecules

unit size :

1 mg (also 10 mg, 50 mg)

purity :

98%

observed molecular weight :

369.8

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent allosteric mGlu7-selective receptor antagonist. Inhibits agonist-induced intracellular calcium mobilization and cAMP accumulation (IC50 values are 26 and 610 nM). Displays intrinsic activity; increases forskolin-induced cAMP accumulation in the absence of an agonist (IC50 = 15 nM), indicating inverse agonist activity.

catalog number base :

2963

product keywords :

Potent allosteric mGlu7 mGluR7-selective antagonists Group III Receptors Glutamate Metabotropic NAM Glutamate (Metabotropic) Group III Receptors 2963,

extended description :

Potent and selective negative allosteric modulator of mGlu7 receptors

chemical name text :

6-(4-Methoxyphenyl)-5-methyl-3-(4-pyridinyl)-isoxazolo[4,5-c]pyridin-4(5H)-one hydrochloride

formula :

C 19 H 15 N 3 O 3 .HCl

formula text :

C19H15N3O3.HCl

cas num :

479077-02-6

2020 USD :

2021 USD :

82 USD

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage