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company name :
Tocris Bioscience
product type :
chemical
product name :
Batimastat
catalog :
2961/1
quantity :
1 mg (also 10 mg)
price :
197 USD
more info or order :
citations: 35
Reference
Orth He E, Huang H, Rao S, Wang Q, Chen Q, O Mara C, et al. Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation. Cell Rep. 2023;42:111965 pubmed publisher
Baggen J, Thibaut H, Hurdiss D, Wahedi M, Marceau C, van Vliet A, et al. Identification of the Cell-Surface Protease ADAM9 as an Entry Factor for Encephalomyocarditis Virus. MBio. 2019;10: pubmed publisher
Pitt J, Wilcox K, Tortelli V, Diniz L, Oliveira M, Dobbins C, et al. Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound A? oligomers. Mol Biol Cell. 2017;28:2623-2636 pubmed publisher
Sanz R, Ferraro G, Girouard M, Fournier A. Ectodomain shedding of Limbic System-Associated Membrane Protein (LSAMP) by ADAM Metallopeptidases promotes neurite outgrowth in DRG neurons. Sci Rep. 2017;7:7961 pubmed publisher
Lim Y, Lee M, Jeong H, Kim H. Involvement of PI3K and MMP1 in PDGF-induced Migration of Human Adipose-derived Stem Cells. Dev Reprod. 2017;21:167-180 pubmed publisher
Ren Z, Chen J, Khalil R. Zymography as a Research Tool in the Study of Matrix Metalloproteinase Inhibitors. Methods Mol Biol. 2017;1626:79-102 pubmed publisher
Carroll M, Kapur A, Felder M, Patankar M, Kreeger P. M2 macrophages induce ovarian cancer cell proliferation via a heparin binding epidermal growth factor/matrix metalloproteinase 9 intercellular feedback loop. Oncotarget. 2016;7:86608-86620 pubmed publisher
Sanz R, Ferraro G, Fournier A. IgLON cell adhesion molecules are shed from the cell surface of cortical neurons to promote neuronal growth. J Biol Chem. 2015;290:4330-42 pubmed publisher
Feng Z, Jia X, Adams M, Ghosh S, Bonomo R, Weinberg A. Epithelial innate immune response to Acinetobacter baumannii challenge. Infect Immun. 2014;82:4458-65 pubmed publisher
Esteso G, Luzón E, Sarmiento E, Gómez Caro R, Steinle A, Murphy G, et al. Altered microRNA expression after infection with human cytomegalovirus leads to TIMP3 downregulation and increased shedding of metalloprotease substrates, including MICA. J Immunol. 2014;193:1344-52 pubmed publisher
Siwetz M, Blaschitz A, Kremshofer J, Bilic J, Desoye G, Huppertz B, et al. Metalloprotease dependent release of placenta derived fractalkine. Mediators Inflamm. 2014;2014:839290 pubmed publisher
Ji Y, Hwang Y, Mood K, Cho H, Lee H, Winterbottom E, et al. EphrinB2 affects apical constriction in Xenopus embryos and is regulated by ADAM10 and flotillin-1. Nat Commun. 2014;5:3516 pubmed publisher
Wojtalewicz N, Sadeqzadeh E, Weiß J, Tehrani M, Klein Scory S, Hahn S, et al. A soluble form of the giant cadherin Fat1 is released from pancreatic cancer cells by ADAM10 mediated ectodomain shedding. PLoS ONE. 2014;9:e90461 pubmed publisher
Zhou C, Petroll W. MMP regulation of corneal keratocyte motility and mechanics in 3-D collagen matrices. Exp Eye Res. 2014;121:147-60 pubmed publisher
Wang L, Cossette S, Rarick K, Gershan J, Dwinell M, Harder D, et al. Astrocytes directly influence tumor cell invasion and metastasis in vivo. PLoS ONE. 2013;8:e80933 pubmed publisher
Woods N, Padmanabhan J. Inhibition of amyloid precursor protein processing enhances gemcitabine-mediated cytotoxicity in pancreatic cancer cells. J Biol Chem. 2013;288:30114-24 pubmed publisher
Yoo J, Rodriguez Perez C, Nie W, Sinnett Smith J, Rozengurt E. TNF-? and LPA promote synergistic expression of COX-2 in human colonic myofibroblasts: role of LPA-mediated transactivation of upregulated EGFR. BMC Gastroenterol. 2013;13:90 pubmed publisher
Howard L, Wyatt S, Nagappan G, Davies A. ProNGF promotes neurite growth from a subset of NGF-dependent neurons by a p75NTR-dependent mechanism. Development. 2013;140:2108-17 pubmed publisher
Fröhlich C, Klitgaard M, Noer J, Kotzsch A, Nehammer C, Kronqvist P, et al. ADAM12 is expressed in the tumour vasculature and mediates ectodomain shedding of several membrane-anchored endothelial proteins. Biochem J. 2013;452:97-109 pubmed publisher
Brafman D, Phung C, Kumar N, Willert K. Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions. Cell Death Differ. 2013;20:369-81 pubmed publisher
Yurtsever Z, Sala Rabanal M, Randolph D, Scheaffer S, Roswit W, Alevy Y, et al. Self-cleavage of human CLCA1 protein by a novel internal metalloprotease domain controls calcium-activated chloride channel activation. J Biol Chem. 2012;287:42138-49 pubmed publisher
Kim S, Cho Y, Kim H, Oh J, Ahn E, Ko H, et al. Antagonism of VEGF-A-induced increase in vascular permeability by an integrin ?3?1-Shp-1-cAMP/PKA pathway. Blood. 2012;120:4892-902 pubmed publisher
Mezil L, Berruyer Pouyet C, Cabaud O, Josselin E, Combes S, Brunel J, et al. Tumor selective cytotoxic action of a thiomorpholin hydroxamate inhibitor (TMI-1) in breast cancer. PLoS ONE. 2012;7:e43409 pubmed publisher
Jijon H, Buret A, Hirota C, Hollenberg M, Beck P. The EGF receptor and HER2 participate in TNF-?-dependent MAPK activation and IL-8 secretion in intestinal epithelial cells. Mediators Inflamm. 2012;2012:207398 pubmed publisher
Kalous A, Nangle M, Anastasía A, Hempstead B, Keast J. Neurotrophic actions initiated by proNGF in adult sensory neurons may require peri-somatic glia to drive local cleavage to NGF. J Neurochem. 2012;122:523-36 pubmed publisher
Yin Z, Sada A, Reslan O, Narula N, Khalil R. Increased MMPs expression and decreased contraction in the rat myometrium during pregnancy and in response to prolonged stretch and sex hormones. Am J Physiol Endocrinol Metab. 2012;303:E55-70 pubmed publisher
Itagaki K, Naito T, Iwakiri R, Haga M, Miura S, Saito Y, et al. Eukaryotic translation elongation factor 1A induces anoikis by triggering cell detachment. J Biol Chem. 2012;287:16037-46 pubmed publisher
Prendergast A, Linbo T, Swarts T, Ungos J, McGraw H, Krispin S, et al. The metalloproteinase inhibitor Reck is essential for zebrafish DRG development. Development. 2012;139:1141-52 pubmed publisher
Kim J, Lee J, Kim S, Choi Y, Lee W, Jeong M, et al. Thrombin-induced Migration and Matrix Metalloproteinase-9 Expression Are Regulated by MAPK and PI3K Pathways in C6 Glioma Cells. Korean J Physiol Pharmacol. 2011;15:211-6 pubmed publisher
Kwon C, Cheng P, King I, Andersen P, Shenje L, Nigam V, et al. Notch post-translationally regulates ?-catenin protein in stem and progenitor cells. Nat Cell Biol. 2011;13:1244-51 pubmed publisher
Hamasaki H, Koga K, Aoki M, Hamasaki M, Koshikawa N, Seiki M, et al. Expression of laminin 5-?2 chain in cutaneous squamous cell carcinoma and its role in tumour invasion. Br J Cancer. 2011;105:824-32 pubmed publisher
Park C, Shin T, Lee H, Kim S, Lee W. Matrix metalloproteinase inhibitors attenuate neuroinflammation following focal cerebral ischemia in mice. Korean J Physiol Pharmacol. 2011;15:115-22 pubmed publisher
Walsh L, Damjanovski S. IGF-1 increases invasive potential of MCF 7 breast cancer cells and induces activation of latent TGF-?1 resulting in epithelial to mesenchymal transition. Cell Commun Signal. 2011;9:10 pubmed publisher
Sims J, McCready J, Jay D. Extracellular heat shock protein (Hsp)70 and Hsp90? assist in matrix metalloproteinase-2 activation and breast cancer cell migration and invasion. PLoS ONE. 2011;6:e18848 pubmed publisher
Dang M, Dubbin K, D Aiello A, Hartmann M, Lodish H, Herrlich A. Epidermal growth factor (EGF) ligand release by substrate-specific a disintegrin and metalloproteases (ADAMs) involves different protein kinase C (PKC) isoenzymes depending on the stimulus. J Biol Chem. 2011;286:17704-13 pubmed publisher
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
2961
SKU :
2961/1
product name :
Batimastat
description :
Potent, broad spectrum MMP inhibitor
target :
Synthetic Metalloprotease Inhibitors
unit size :
1 mg (also 10 mg)
category :
Small Molecules
purity :
99%
storage :
Store at -20°C
observed molecular weight :
477.64
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Batimastat is a potent, broad spectrum MMP inhibitor (IC50 values are 3, 4, 4, 6 and 20 nM for MMP -1, -2, -9, -7 and -3 respectively). Exhibits antiproliferative, anti-invasive and antimetastatic activity in human ovarian carcinoma xenografts in vivo .
product keywords :
Potent broad spectrum MMP inhibitors inhibits Matrixins Matrix Metalloproteinase Metalloprotease Proteinases Proteases BB-94 Matrix Metalloprotease 2961,
extended description :
Potent, broad spectrum MMP inhibitor
chemical name text :
(2R,3S)-N4-Hydroxy-N1-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]butanediamide
formula :
C23H31N3O4S2
formula text :
C23H31N3O4S2
cas num :
130370-60-4
USD :
189
USD 2025 :
197 USD
product details :
Potent, broad spectrum MMP inhibitor
alt names :
BB-94
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK