Picropodophyllotoxin | Tocris Bioscience 2956 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Picropodophyllotoxin

catalog :

2956

quantity :

10 mg

price :

223 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Forster R, Sarginson A, Velichkova A, Hogg C, Dorning A, Horne A, et al. Macrophage-derived insulin-like growth factor-1 is a key neurotrophic and nerve-sensitizing factor in pain associated with endometriosis. FASEB J. 2019;33:11210-11222 pubmed publisher
Tarnowski M, Tkacz M, Zgutka K, Bujak J, Kopytko P, Pawlik A. Picropodophyllin (PPP) is a potent rhabdomyosarcoma growth inhibitor both in vitro and in vivo. BMC Cancer. 2017;17:532 pubmed publisher
Stouffer M, Woods C, Patel J, Lee C, Witkovsky P, Bao L, et al. Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward. Nat Commun. 2015;6:8543 pubmed publisher

product information

brand :

Tocris

master code :

2956

SKU :

2956/10

product name :

Picropodophyllotoxin

description :

Selective IGF1R inhibitor

target :

Insulin and Insulin-like Receptor Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

97%

observed molecular weight :

414.41

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Orally active insulin-like growth factor 1 receptor (IGF1R) inhibitor that exhibits no activity at the insulin receptor, FGFR, PDGFR or EGFR. Inhibits IGF1R autophosphorylation (IC50 ~ 1 nM), increases the fraction of cells in the G2/M phase and upregulates apoptosis. Exhibits antiproliferative effects in multiple cancer cell lines (IC50 = 0.05 - 15 M), and has anticancer and antineovascularization activity in vivo .

catalog number base :

2956

product keywords :

Selective IGF1R inhibitors inhibits Receptors Insulin-like Receptor Tyrosine Kinases RTKs Picropodopyhllin Picropodophyllin Insulin and insulin-like Receptors Insulin and Insulin-like Receptors 2956,

extended description :

Selective IGF1R inhibitor

chemical name text :

(5R,5aS,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3 ,4 :6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one

formula :

C 22 H 22 O 8

formula text :

C22H22O8

cas num :

477-47-4

2020 USD :

216

2021 USD :

223 USD

alt names :

Picropodophyllin

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage