Picropodophyllotoxin | Tocris Bioscience 2956/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Picropodophyllotoxin

catalog :

2956/10

quantity :

10 mg

price :

281 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Forster R, Sarginson A, Velichkova A, Hogg C, Dorning A, Horne A, et al. Macrophage-derived insulin-like growth factor-1 is a key neurotrophic and nerve-sensitizing factor in pain associated with endometriosis. FASEB J. 2019;33:11210-11222 pubmed publisher
Tarnowski M, Tkacz M, Zgutka K, Bujak J, Kopytko P, Pawlik A. Picropodophyllin (PPP) is a potent rhabdomyosarcoma growth inhibitor both in vitro and in vivo. BMC Cancer. 2017;17:532 pubmed publisher
Tejada T, Tan L, Torres R, Calvert J, Lambert J, Zaidi M, et al. IGF-1 degradation by mouse mast cell protease 4 promotes cell death and adverse cardiac remodeling days after a myocardial infarction. Proc Natl Acad Sci U S A. 2016;113:6949-54 pubmed publisher
Stouffer M, Woods C, Patel J, Lee C, Witkovsky P, Bao L, et al. Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward. Nat Commun. 2015;6:8543 pubmed publisher
Wiener Z, Band A, Kallio P, Högström J, Hyvönen V, Kaijalainen S, et al. Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-β. Proc Natl Acad Sci U S A. 2014;111:E2229-36 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2956

SKU :

2956/10

product name :

Picropodophyllotoxin

description :

Selective IGF1R inhibitor

target :

Insulin and Insulin-like Receptor Inhibitors

unit size :

10 mg

category :

Small Molecules

purity :

97%

storage :

Store at +4°C

observed molecular weight :

414.41

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Picropodophyllotoxin is an orally active insulin-like growth factor 1 receptor (IGF1R) inhibitor that exhibits no activity at the insulin receptor, FGFR, PDGFR or EGFR. Inhibits IGF1R autophosphorylation (IC50 ~ 1 nM), increases the fraction of cells in the G2/M phase and upregulates apoptosis. Exhibits antiproliferative effects in multiple cancer cell lines (IC50 = 0.05 - 15 M), and has anticancer and antineovascularization activity in vivo .

product keywords :

Selective IGF1R inhibitors inhibits Receptors Insulin-like Receptor Tyrosine Kinases RTKs Picropodopyhllin Picropodophyllin Insulin and insulin-like Receptors Insulin and Insulin-like Receptors 2956,

extended description :

Selective IGF1R inhibitor

chemical name text :

(5R,5aS,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3 ,4 :6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one

formula :

C22H22O8

formula text :

C22H22O8

cas num :

477-47-4

USD :

278

USD 2025 :

281 USD

product details :

Selective IGF1R inhibitor

alt names :

Picropodophyllin

more info or order :

Tocris Bioscience product webpage