PX 12 | Tocris Bioscience 2954/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PX 12

catalog :

2954/10

quantity :

10 mg (also 50 mg)

price :

161 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Shin H, You B, Park W. PX-12-induced HeLa cell death is associated with oxidative stress and GSH depletion. Oncol Lett. 2013;6:1804-1810 pubmed
Zhu J, Sun L, Lin S, Zhao R, Zhou L, Fang D, et al. BlyS is up-regulated by hypoxia and promotes migration of human breast cancer cells. J Exp Clin Cancer Res. 2012;31:31 pubmed publisher

product information

brand :

Tocris

master code :

2954

SKU :

2954/10

product name :

PX 12

description :

Thioredoxin-1 inhibitor

target :

Other Reductase Inhibitors

category :

Small Molecules

unit sizes :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

188.31

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PX 12 is a thioredoxin-1 (Trx-1) inhibitor; irreversibly inactivates Trx-1 as a substrate for reduction by thioredoxin reductase (TR); competitively inhibits the reduction of Trx-1 by TR (Ki = 30.8 M). Attenuates expression of HIF-1 , VEGF and iNOS (IC50 values are 7.2, 10.4 and 18.1 M respectively). Exhibits antitumor activity; directly inhibits tubulin in vitro and decreases tumor microvessel density in vivo .

extended description :

Thioredoxin-1 inhibitor

chemical name text :

2-[(1-Methylpropyl)dithio]-1H-imidazole

formula :

C 7 H 12 N 2 S 2

formula text :

C7H12N2S2

cas num :

141400-58-0

USD :

161 USD

product details :

Thioredoxin-1 inhibitor

alt names :

IV-2

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage