TRAM 34 | Tocris Bioscience 2946/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TRAM 34

catalog :

2946/10

quantity :

10 mg (also 50 mg)

price :

193 USD

more info or order :

Tocris Bioscience product webpage

citations: 11

Reference
Gaertner S, Auger C, Farooq M, Pollet B, Khemais Benkhiat S, Niazi Z, et al. Oral Intake of EPA:DHA 6:1 by Middle-Aged Rats for One Week Improves Age-Related Endothelial Dysfunction in Both the Femoral Artery and Vein: Role of Cyclooxygenases. Int J Mol Sci. 2020;21: pubmed publisher
Yu Z, Wang Y, Qin L, Chen H. Functional Cooperation between KCa3.1 and TRPV4 Channels in Bronchial Smooth Muscle Cell Proliferation Associated with Chronic Asthma. Front Pharmacol. 2017;8:559 pubmed publisher
Chien C, Su M. 5-hydroxytryptamine has an endothelium-derived hyperpolarizing factor-like effect on coronary flow in isolated rat hearts. J Biomed Sci. 2015;22:42 pubmed publisher
Cahalan S, Lukacs V, Ranade S, Chien S, Bandell M, Patapoutian A. Piezo1 links mechanical forces to red blood cell volume. elife. 2015;4: pubmed publisher
Mazzuca M, Mata K, Li W, Rangan S, Khalil R. Estrogen receptor subtypes mediate distinct microvascular dilation and reduction in [Ca2+]I in mesenteric microvessels of female rat. J Pharmacol Exp Ther. 2015;352:291-304 pubmed publisher
Kanthesh B, Sandle G, Rajendran V. Enhanced K(+) secretion in dextran sulfate-induced colitis reflects upregulation of large conductance apical K(+) channels (BK; Kcnma1). Am J Physiol Cell Physiol. 2013;305:C972-80 pubmed publisher
Agarwal J, Zhu Y, Zhang Q, Mongin A, Hough L. TRAM-34, a putatively selective blocker of intermediate-conductance, calcium-activated potassium channels, inhibits cytochrome P450 activity. PLoS ONE. 2013;8:e63028 pubmed publisher
Benton M, Lewis A, Bant J, Raman I. Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somata. J Neurophysiol. 2013;109:2528-41 pubmed publisher
Engbers J, Anderson D, Asmara H, Rehak R, Mehaffey W, Hameed S, et al. Intermediate conductance calcium-activated potassium channels modulate summation of parallel fiber input in cerebellar Purkinje cells. Proc Natl Acad Sci U S A. 2012;109:2601-6 pubmed publisher
Zemkova H, Stojilkovic S, Klein D. Norepinephrine causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+. Endocrinology. 2011;152:3842-51 pubmed publisher
Chan S, Cipolla M. Relaxin causes selective outward remodeling of brain parenchymal arterioles via activation of peroxisome proliferator-activated receptor-?. FASEB J. 2011;25:3229-39 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2946

SKU :

2946/10

product name :

TRAM 34

description :

Potent and highly selective KCa3.1 (IK) channel blocker

target :

Ca2+-Activated Potassium Channel Blockers

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

99%

storage :

Store at +4°C

observed molecular weight :

344.84

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

TRAM 34 is a potent and highly selective blocker of intermediate conductance Ca2+-activated K+ channels (KCa3.1) (Kd = 20 nM). Exhibits 200-1500-fold selectivity over KV, BKCa, KCa2, Na+, CRAC and Cl- channels. Suppresses the reactivation of lymphocytes by mitogenic stimuli.

product keywords :

selective IKCa1 channel blockers Potassium KCa Channels ca2+-activated ca2+-dependent K+ TRAM34 KCa3.1 Ca2+-Activated Potassium Channels 2946,

extended description :

Potent and highly selective KCa3.1 (IK) channel blocker

chemical name text :

1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole

formula :

C22H17ClN2

formula text :

C22H17ClN2

cas num :

289905-88-0

USD :

191

USD 2025 :

193 USD

product details :

Potent and highly selective KCa3.1 (IK) channel blocker

more info or order :

Tocris Bioscience product webpage