PI 103 hydrochloride | Tocris Bioscience 2930/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PI 103 hydrochloride

catalog :

2930/1

quantity :

1 mg (also 10 mg)

price :

133 USD

more info or order :

Tocris Bioscience product webpage

citations: 13

Reference
Genga R, Kernfeld E, Parsi K, Parsons T, Ziller M, Maehr R. Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development. Cell Rep. 2019;27:708-718.e10 pubmed publisher
Rostovskaya M, Stirparo G, Smith A. Capacitation of human naïve pluripotent stem cells for multi-lineage differentiation. Development. 2019;146: pubmed publisher
Guo G, von Meyenn F, Rostovskaya M, Clarke J, Dietmann S, Baker D, et al. Epigenetic resetting of human pluripotency. Development. 2017;144:2748-2763 pubmed publisher
Rider C, Shah S, Miller Larsson A, Giembycz M, Newton R. Cytokine-induced loss of glucocorticoid function: effect of kinase inhibitors, long-acting β(2)-adrenoceptor [corrected] agonist and glucocorticoid receptor ligands. PLoS ONE. 2015;10:e0116773 pubmed publisher
Li C, Zhang E, Sun Y, Lee P, Zhan Y, Guo Y, et al. Rapamycin-insensitive up-regulation of adipocyte phospholipase A2 in tuberous sclerosis and lymphangioleiomyomatosis. PLoS ONE. 2014;9:e104809 pubmed publisher
Brown M, Dobrikov M, Gromeier M. Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated translation and viral oncolysis. J Virol. 2014;88:13149-60 pubmed publisher
Engels M, Rajarajan K, Feistritzer R, Sharma A, Nielsen U, Schalij M, et al. Insulin-like growth factor promotes cardiac lineage induction in vitro by selective expansion of early mesoderm. Stem Cells. 2014;32:1493-502 pubmed publisher
Li C, Lee P, Sun Y, Gu X, Zhang E, Guo Y, et al. Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells. J Exp Med. 2014;211:15-28 pubmed publisher
Montané M, Menand B. ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change. J Exp Bot. 2013;64:4361-74 pubmed publisher
Campbell A, Lawn S, McGarry L, Welch H, Ozanne B, Norman J. P-Rex1 cooperates with PDGFR? to drive cellular migration in 3D microenvironments. PLoS ONE. 2013;8:e53982 pubmed publisher
Peng F, Yao H, Akturk H, Buch S. Platelet-derived growth factor CC-mediated neuroprotection against HIV Tat involves TRPC-mediated inactivation of GSK 3beta. PLoS ONE. 2012;7:e47572 pubmed publisher
Balzarolo M, Karrich J, Engels S, Blom B, Medema J, Wolkers M. The transcriptional regulator NAB2 reveals a two-step induction of TRAIL in activated plasmacytoid DCs. Eur J Immunol. 2012;42:3019-27 pubmed publisher
Makhortova N, Hayhurst M, Cerqueira A, Sinor Anderson A, Zhao W, Heiser P, et al. A screen for regulators of survival of motor neuron protein levels. Nat Chem Biol. 2011;7:544-52 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2930

SKU :

2930/1

product name :

PI 103 hydrochloride

description :

Inhibitor of PI 3-kinase, mTOR and DNA-PK

target :

PI 3-Kinase Inhibitors

unit size :

1 mg (also 10 mg)

category :

Small Molecules

purity :

98%

storage :

Desiccate at +4°C

observed molecular weight :

384.82

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PI 103 hydrochloride is an inhibitor of DNA-PK, PI 3-kinase (p110 ) and mTOR (IC50 values are 2, 8, 20, 26, 48, 83, 88, 150, 850, 920, ~ 1000 and 2300 nM for DNA-PK, p110 , mTORC1, PI 3-KC2 , p110 , mTORC2, p110 , p110 , ATR, ATM, PI 3-KC2 and hsVPS34 respectively). Inhibits growth of human tumor xenografts in mice in vivo . Induces autophagosome formation in glioma cells.

product keywords :

inhibitors inhibits DNA-PK mTOR PI 3-kinase DNA-Dependent Protein Kinases Mammalian Target Rapamycin PI103 hydrochloride PI 3-Kinase mTOR DNA-dependent Protein Kinase Inositol Lipids Checkpoint Control Kinases Autophagy 2930,

extended description :

Inhibitor of PI 3-kinase, mTOR and DNA-PK

chemical name text :

3-[4-(4-Morpholinylpyrido[3 ,2 :4,5]furo[3,2-d]pyrimidin-2-yl]phenol hydrochloride

formula :

C19H16N4O3.HCl

formula text :

C19H16N4O3.HCl

cas num :

371935-79-4

USD :

129

USD 2025 :

133 USD

product details :

Inhibitor of PI 3-kinase, mTOR and DNA-PK

more info or order :

Tocris Bioscience product webpage