product summary
Loading...
company name :
Tocris Bioscience
product type :
chemical
product name :
MTEP hydrochloride
catalog :
2921/10
quantity :
10 mg (also 50 mg)
price :
223 USD
more info or order :
citations: 11
Reference
Lim D, Mapelli L, Canonico P, Moccia F, Genazzani A. Neuronal Activity-Dependent Activation of Astroglial Calcineurin in Mouse Primary Hippocampal Cultures. Int J Mol Sci. 2018;19: pubmed publisher
Thomson S, Seo S, Barnes S, Louros S, Muscas M, Dando O, et al. Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome. Neuron. 2017;95:550-563.e5 pubmed publisher
Arsenault D, Coulombe K, Zhu A, Gong C, Kil K, Choi J, et al. Loss of Metabotropic Glutamate Receptor 5 Function on Peripheral Benzodiazepine Receptor in Mice Prenatally Exposed to LPS. PLoS ONE. 2015;10:e0142093 pubmed publisher
Rosa J, Bos R, Sack G, Fortuny C, Agarwal A, Bergles D, et al. Neuron-glia signaling in developing retina mediated by neurotransmitter spillover. elife. 2015;4: pubmed publisher
Guimaraes I, Carvalho T, Ferguson S, Pereira G, Ribeiro F. The metabotropic glutamate receptor 5 role on motor behavior involves specific neural substrates. Mol Brain. 2015;8:24 pubmed publisher
Pollard M, Bartolome J, Conn P, Steckler T, Shaban H. Modulation of neuronal microcircuit activities within the medial prefrontal cortex by mGluR5 positive allosteric modulator. J Psychopharmacol. 2014;28:935-46 pubmed publisher
Reissner K, Gipson C, Tran P, Knackstedt L, Scofield M, Kalivas P. Glutamate transporter GLT-1 mediates N-acetylcysteine inhibition of cocaine reinstatement. Addict Biol. 2015;20:316-23 pubmed publisher
Jurgens C, Bell K, McQuiston A, Guido W. Optogenetic stimulation of the corticothalamic pathway affects relay cells and GABAergic neurons differently in the mouse visual thalamus. PLoS ONE. 2012;7:e45717 pubmed publisher
Ren B, Gu X, Zheng Y, Liu C, Wang D, Sun Y, et al. Intrathecal injection of metabotropic glutamate receptor subtype 3 and 5 agonist/antagonist attenuates bone cancer pain by inhibition of spinal astrocyte activation in a mouse model. Anesthesiology. 2012;116:122-32 pubmed publisher
Sumislawski J, Ramikie T, Patel S. Reversible gating of endocannabinoid plasticity in the amygdala by chronic stress: a potential role for monoacylglycerol lipase inhibition in the prevention of stress-induced behavioral adaptation. Neuropsychopharmacology. 2011;36:2750-61 pubmed publisher
Tronson N, Guzman Y, Guedea A, Huh K, Gao C, Schwarz M, et al. Metabotropic glutamate receptor 5/Homer interactions underlie stress effects on fear. Biol Psychiatry. 2010;68:1007-15 pubmed publisher
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
2921
SKU :
2921/10
product name :
MTEP hydrochloride
description :
Potent and selective mGlu5 antagonist
target :
Group I mGluR Antagonists
unit size :
10 mg (also 50 mg)
category :
Small Molecules
purity :
99%
storage :
Store at -20°C
observed molecular weight :
236.72
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
MTEP hydrochloride is a potent, selective and non-competitive mGlu5 antagonist (IC50 = 5 nM in Ca2+-flux assay; Ki= 16 nM). Displays anxiolytic activity in vivo and is orally active.
product keywords :
Potent selective mGlu5 mGluR5 antagonists mGlur Group I Receptors Glutamate Metabotropic merck Glutamate (Metabotropic) Group I Receptors 2921,
extended description :
Potent and selective mGlu5 antagonist
chemical name text :
3-((2-Methyl-1,3-thiazol-4-yl)ethynyl)pyridine hydrochloride
formula :
C11H8N2S.HCl
formula text :
C11H8N2S.HCl
cas num :
1186195-60-7
USD :
216
USD 2025 :
223 USD
product details :
Potent and selective mGlu5 antagonist
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK