product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
Veratridine
catalog :
2918/10
quantity :
10 mg (also 50 mg)
price :
128 USD
more info or order :
citations: 6
Reference
McKeithan W, Savchenko A, YU M, Cerignoli F, Bruyneel A, Price J, et al. An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes. Front Physiol. 2017;8:766 pubmed publisher
Agarwal A, Wu P, Hughes E, Fukaya M, Tischfield M, Langseth A, et al. Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes. Neuron. 2017;93:587-605.e7 pubmed publisher
Bedut S, Seminatore Nole C, Lamamy V, Caignard S, Boutin J, Nosjean O, et al. High-throughput drug profiling with voltage- and calcium-sensitive fluorescent probes in human iPSC-derived cardiomyocytes. Am J Physiol Heart Circ Physiol. 2016;311:H44-53 pubmed publisher
Battefeld A, Klooster J, Kole M. Myelinating satellite oligodendrocytes are integrated in a glial syncytium constraining neuronal high-frequency activity. Nat Commun. 2016;7:11298 pubmed publisher
Jones A, Kainz D, Khan F, Lee C, Carrithers M. Human macrophage SCN5A activates an innate immune signaling pathway for antiviral host defense. J Biol Chem. 2014;289:35326-40 pubmed publisher
Malmersjö S, Rebellato P, Smedler E, Planert H, Kanatani S, Liste I, et al. Neural progenitors organize in small-world networks to promote cell proliferation. Proc Natl Acad Sci U S A. 2013;110:E1524-32 pubmed publisher
product information
brand :
Tocris
master code :
2918
SKU :
2918/10
product name :
Veratridine
description :
Voltage-gated Na+ channel opener
target :
Additional Voltage-gated Sodium Channel Products
category :
Small Molecules
unit sizes :
10 mg (also 50 mg)
purity :
98%
observed molecular weight :
673.79
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Veratridine is a voltage-gated Na+ channel opener; increases intracellular Ca2+ with no effect on the Na+/Ca2+ exchanger. Steroid-derived alkaloid neurotoxin. Increases membrane Na+ permeability and depolarizes excitable tissues.
extended description :
Voltage-gated Na+ channel opener
chemical name text :
4 ,9-Epoxy-3 -veratroyloxy-5 -cevan-4 ,12,14,16 ,17,20-hexaol
formula :
C 36 H 51 NO 11
formula text :
C36H51NO11
cas num :
71-62-5
USD :
128 USD
product details :
Voltage-gated Na+ channel opener
storage :
Store at -20°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK