SU 9516 | Tocris Bioscience 2907 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SU 9516

catalog :

2907

quantity :

10 mg (also 50 mg)

price :

152 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Pollet M, Shaik S, Mescher M, Frauenstein K, Tigges J, Braun S, et al. The AHR represses nucleotide excision repair and apoptosis and contributes to UV-induced skin carcinogenesis. Cell Death Differ. 2018;25:1823-1836 pubmed publisher
Shi H, Fu C, Wang W, Li Y, Du S, Cao R, et al. The FGF-1-specific single-chain antibody scFv1C9 effectively inhibits breast cancer tumour growth and metastasis. J Cell Mol Med. 2014;18:2061-70 pubmed publisher

product information

brand :

Tocris

master code :

2907

SKU :

2907/10

product name :

SU 9516

description :

Cdk inhibitor; potently inhibits cdk1 and cdk2

target :

Cyclin-dependent Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

241.25

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 0.02 - 0.03, 0.04 - 0.2, 0.2 - 1.7 and 0.9 M for cdk2, cdk1, cdk4 and cdk9, respectively). Inhibits pRb phosphorylation causing enhanced pRB/E2F complex formation and induces G1 and G2-M cell cycle arrest. Transcriptionally downregulates Mcl-1 and has antiproliferative, cytostatic and pro-apoptotic effects in vitro .

catalog number base :

2907

product keywords :

Potent cdk2 inhibitors inhibits Transcriptionally downregulates Mcl-1 proapoptotic Cyclin-Dependent Protein Kinases Bcl-2 Family SU9516 Cyclin-dependent Kinase Bcl-2 Family 2907,

extended description :

Cdk inhibitor; potently inhibits cdk1 and cdk2

chemical name text :

(Z)-1,3-Dihydro-3-(1H-imidazol-4-ylmethylene)-5-methoxy-2H-indol-2-one

formula :

C 13 H 11 N 3 O 2

formula text :

C13H11N3O2

cas num :

377090-84-1

2020 USD :

149

2021 USD :

152 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage