D 4476 | Tocris Bioscience 2902/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

D 4476

catalog :

2902/10

quantity :

10 mg (also 50 mg)

price :

277 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Bartley C, O Keefe R, Blice Baum A, Mihailescu M, Gong X, Miyares L, et al. Mammalian FMRP S499 Is Phosphorylated by CK2 and Promotes Secondary Phosphorylation of FMRP. Eneuro. 2016;3: pubmed
Zhang B, Zhang T, Wang G, Wang G, Chi W, Jiang Q, et al. GSK3Î²-Dzip1-Rab8 cascade regulates ciliogenesis after mitosis. PLoS Biol. 2015;13:e1002129 pubmed publisher
Järås M, Miller P, Chu L, Puram R, Fink E, Schneider R, et al. Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia. J Exp Med. 2014;211:605-12 pubmed publisher
Zemp I, Wandrey F, Rao S, Ashiono C, Wyler E, Montellese C, et al. CK1? and CK1? are components of human 40S subunit precursors required for cytoplasmic 40S maturation. J Cell Sci. 2014;127:1242-53 pubmed publisher
Qian J, Zheng H, HuangFu W, Liu J, Carbone C, Leu N, et al. Pathogen recognition receptor signaling accelerates phosphorylation-dependent degradation of IFNAR1. PLoS Pathog. 2011;7:e1002065 pubmed publisher
Probst Kepper M, Kröger A, Garritsen H, Buer J. Perspectives on Regulatory T Cell Therapies. Transfus Med Hemother. 2009;36:302-308 pubmed

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2902

SKU :

2902/10

product name :

D 4476

description :

Selective CK1 inhibitor. Also inhibits TGF- RI

target :

Casein Kinase 1 Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

99%

storage :

Store at +4°C

observed molecular weight :

398.41

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

D 4476 is a selective inhibitor of casein kinase 1 (CK1) and TGF- type-I receptor (ALK5) that displays 20-fold selectivity over SAPK2/p38 and a much greater selectivity over all other protein kinases tested. Suppresses site-specific phosphorylation and nuclear exclusion of FOXO1a.

product keywords :

Selective CK1 inhibits inhibitors TGF- RI TGF- TGF-betaRI TGFbRI TGFbR1 tgf-b1Casein Kinase 1 Kinases Transforming Growth Factors Beta Receptors TGF-beta RSTK Receptor Serine/Threonine RSTKs D4476 GlaxoSmithKline GSK Casein Kinase 1 TGF-beta Receptors 2902,

extended description :

Selective CK1 inhibitor. Also inhibits TGF- RI

chemical name text :

4-[4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide

formula :

C23H18N4O3

formula text :

C23H18N4O3

cas num :

301836-43-1

USD :

274

USD 2025 :

277 USD

product details :

Selective CK1 inhibitor. Also inhibits TGF- RI

more info or order :

Tocris Bioscience product webpage