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company name :
Tocris Bioscience
product type :
chemical
product name :
SB 242084
catalog :
2901/10
quantity :
10 mg (also 50 mg)
price :
282 USD
more info or order :
citations: 10
Reference
Moutkine I, Quentin E, Guiard B, Maroteaux L, Doly S. Heterodimers of serotonin receptor subtypes 2 are driven by 5-HT2C protomers. J Biol Chem. 2017;292:6352-6368 pubmed publisher
Lo Cicero A, Jaskowiak A, Egesipe A, Tournois J, Brinon B, Pitrez P, et al. A High Throughput Phenotypic Screening reveals compounds that counteract premature osteogenic differentiation of HGPS iPS-derived mesenchymal stem cells. Sci Rep. 2016;6:34798 pubmed publisher
Krishnan B. Amygdala-Hippocampal Phospholipase D (PLD) Signaling As Novel Mechanism of Cocaine-Environment Maladaptive Conditioned Responses. Int J Neuropsychopharmacol. 2016;: pubmed publisher
Ward R, Pediani J, Godin A, Milligan G. Regulation of oligomeric organization of the serotonin 5-hydroxytryptamine 2C (5-HT2C) receptor observed by spatial intensity distribution analysis. J Biol Chem. 2015;290:12844-57 pubmed publisher
Carbonaro T, Eshleman A, Forster M, Cheng K, Rice K, Gatch M. The role of 5-HT2A, 5-HT 2C and mGlu2 receptors in the behavioral effects of tryptamine hallucinogens N,N-dimethyltryptamine and N,N-diisopropyltryptamine in rats and mice. Psychopharmacology (Berl). 2015;232:275-84 pubmed publisher
Goda S, Piasecka J, Olszewski M, Kasicki S, Hunt M. Serotonergic hallucinogens differentially modify gamma and high frequency oscillations in the rat nucleus accumbens. Psychopharmacology (Berl). 2013;228:271-82 pubmed publisher
Zhang Q, Zhu Y, Zhou W, Gao L, Yuan L, Han X. Serotonin receptor 2C and insulin secretion. PLoS ONE. 2013;8:e54250 pubmed publisher
Manvich D, Kimmel H, Howell L. Effects of serotonin 2C receptor agonists on the behavioral and neurochemical effects of cocaine in squirrel monkeys. J Pharmacol Exp Ther. 2012;341:424-34 pubmed publisher
Fouad K, Rank M, Vavrek R, Murray K, Sanelli L, Bennett D. Locomotion after spinal cord injury depends on constitutive activity in serotonin receptors. J Neurophysiol. 2010;104:2975-84 pubmed publisher
Canal C, Olaghere da Silva U, Gresch P, Watt E, Sanders Bush E, Airey D. The serotonin 2C receptor potently modulates the head-twitch response in mice induced by a phenethylamine hallucinogen. Psychopharmacology (Berl). 2010;209:163-74 pubmed publisher
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
2901
SKU :
2901/10
product name :
SB 242084
description :
Selective 5-HT2C antagonist; brain penetrant
target :
5-HT2C Receptor Antagonists
unit size :
10 mg (also 50 mg)
category :
Small Molecules
purity :
99%
storage :
Desiccate at +4°C
observed molecular weight :
467.78
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
SB 242084 is a 5-HT2C receptor antagonist that displays 158- and 100-fold selectivity over 5-HT2A and 5-HT2B receptors respectively. Also displays selectivity over a range of other 5-HT, dopamine and adrenergic receptors. Brain penetrant; exerts anxiolytic-like activity.
product keywords :
Selective 5-HT2C antagonists brain penetrant Serotonin Receptors SB242084 GlaxoSmithKline GSK 5-HT2C Receptors 2901,
extended description :
Selective 5-HT2C antagonist; brain penetrant
chemical name text :
6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyamide dihydrochloride
formula :
C21H19ClN4O2.2HCl
formula text :
C21H19ClN4O2.2HCl
cas num :
1049747-87-6
USD :
270
USD 2025 :
282 USD
product details :
Selective 5-HT2C antagonist; brain penetrant
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK