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company name :
Tocris Bioscience
product type :
chemical
product name :
Dynasore
catalog :
2897/10
quantity :
10 mg (also 50 mg)
price :
193 USD
more info or order :
citations: 33
Reference
Sole L, Wagnon J, Akin E, Meisler M, Tamkun M. The MAP1B Binding Domain of Nav1.6 Is Required for Stable Expression at the Axon Initial Segment. J Neurosci. 2019;39:4238-4251 pubmed publisher
Lorenz Guertin J, Wilcox M, Zhang M, Larsen M, Pilli J, Schmidt B, et al. A versatile optical tool for studying synaptic GABAA receptor trafficking. J Cell Sci. 2017;130:3933-3945 pubmed publisher
Pitt J, Wilcox K, Tortelli V, Diniz L, Oliveira M, Dobbins C, et al. Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound A? oligomers. Mol Biol Cell. 2017;28:2623-2636 pubmed publisher
Hofmann M, Andresen M. Dynasore blocks evoked release while augmenting spontaneous synaptic transmission from primary visceral afferents. PLoS ONE. 2017;12:e0174915 pubmed publisher
Blume L, Leone Kabler S, Luessen D, Marrs G, Lyons E, Bass C, et al. Cannabinoid receptor interacting protein suppresses agonist-driven CB1 receptor internalization and regulates receptor replenishment in an agonist-biased manner. J Neurochem. 2016;139:396-407 pubmed publisher
Hallstrom K, McCormick B. The type three secreted effector SipC regulates the trafficking of PERP during Salmonella infection. Gut Microbes. 2016;7:136-45 pubmed publisher
von Hoven G, Neukirch C, Meyenburg M, Füser S, Petrivna M, Rivas A, et al. eIF2α Confers Cellular Tolerance to S. aureus α-Toxin. Front Immunol. 2015;6:383 pubmed publisher
Petermann P, Rahn E, Thier K, Hsu M, Rixon F, Kopp S, et al. Role of Nectin-1 and Herpesvirus Entry Mediator as Cellular Receptors for Herpes Simplex Virus 1 on Primary Murine Dermal Fibroblasts. J Virol. 2015;89:9407-16 pubmed publisher
Falgairolle M, O Donovan M. Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons. PLoS ONE. 2015;10:e0131430 pubmed publisher
Nimlamool W, Andrews R, Falk M. Connexin43 phosphorylation by PKC and MAPK signals VEGF-mediated gap junction internalization. Mol Biol Cell. 2015;26:2755-68 pubmed publisher
Khatua A, Cheatham A, Kruzel E, Singhal P, Skorecki K, Popik W. Exon 4-encoded sequence is a major determinant of cytotoxicity of apolipoprotein L1. Am J Physiol Cell Physiol. 2015;309:C22-37 pubmed publisher
Niederst E, Reyna S, Goldstein L. Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing. Mol Biol Cell. 2015;26:205-17 pubmed publisher
Lee W, Leddy H, Chen Y, Lee S, Zelenski N, McNulty A, et al. Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage. Proc Natl Acad Sci U S A. 2014;111:E5114-22 pubmed publisher
Ledonne A, Nobili A, Latagliata E, Cavallucci V, Guatteo E, Puglisi Allegra S, et al. Neuregulin 1 signalling modulates mGluR1 function in mesencephalic dopaminergic neurons. Mol Psychiatry. 2015;20:959-73 pubmed publisher
Weber K, Schilling J. Lysosomes integrate metabolic-inflammatory cross-talk in primary macrophage inflammasome activation. J Biol Chem. 2014;289:9158-71 pubmed publisher
Chandrasekaran P, Moore V, Buckley M, Spurrier J, Kehrl J, Venkatesan S. HIV-1 Nef down-modulates C-C and C-X-C chemokine receptors via ubiquitin and ubiquitin-independent mechanism. PLoS ONE. 2014;9:e86998 pubmed publisher
Pribiag H, Stellwagen D. TNF-? downregulates inhibitory neurotransmission through protein phosphatase 1-dependent trafficking of GABA(A) receptors. J Neurosci. 2013;33:15879-93 pubmed publisher
Marcello E, Saraceno C, Musardo S, Vara H, de la Fuente A, Pelucchi S, et al. Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease. J Clin Invest. 2013;123:2523-38 pubmed publisher
Chandrasekaran P, Buckley M, Moore V, Wang L, Kehrl J, Venkatesan S. HIV-1 Nef impairs heterotrimeric G-protein signaling by targeting G?(i2) for degradation through ubiquitination. J Biol Chem. 2012;287:41481-98 pubmed publisher
Chen P, Douglas S, Meshki J, Tuluc F. Neurokinin 1 receptor mediates membrane blebbing and sheer stress-induced microparticle formation in HEK293 cells. PLoS ONE. 2012;7:e45322 pubmed
Hollidge B, Nedelsky N, Salzano M, Fraser J, Gonzalez Scarano F, Soldan S. Orthobunyavirus entry into neurons and other mammalian cells occurs via clathrin-mediated endocytosis and requires trafficking into early endosomes. J Virol. 2012;86:7988-8001 pubmed publisher
Bassani S, Cingolani L, Valnegri P, Folci A, Zapata J, Gianfelice A, et al. The X-linked intellectual disability protein TSPAN7 regulates excitatory synapse development and AMPAR trafficking. Neuron. 2012;73:1143-58 pubmed publisher
Lee J, Ho W, Lee S. Actin-dependent rapid recruitment of reluctant synaptic vesicles into a fast-releasing vesicle pool. Proc Natl Acad Sci U S A. 2012;109:E765-74 pubmed publisher
Rahn E, Petermann P, Hsu M, Rixon F, Knebel Mörsdorf D. Entry pathways of herpes simplex virus type 1 into human keratinocytes are dynamin- and cholesterol-dependent. PLoS ONE. 2011;6:e25464 pubmed publisher
Rodriguez J, Luria Pérez R, López Valdés H, Casero D, Daniels T, Patel S, et al. Lethal iron deprivation induced by non-neutralizing antibodies targeting transferrin receptor 1 in malignant B cells. Leuk Lymphoma. 2011;52:2169-78 pubmed publisher
Zemskov E, Mikhailenko I, Hsia R, Zaritskaya L, Belkin A. Unconventional secretion of tissue transglutaminase involves phospholipid-dependent delivery into recycling endosomes. PLoS ONE. 2011;6:e19414 pubmed publisher
Yang M, Reich D, Chen C. Measurement and analysis of traction force dynamics in response to vasoactive agonists. Integr Biol (Camb). 2011;3:663-74 pubmed publisher
Lussier M, Nasu Nishimura Y, Roche K. Activity-dependent ubiquitination of the AMPA receptor subunit GluA2. J Neurosci. 2011;31:3077-81 pubmed publisher
Lowther K, Nikolaev V, Mehlmann L. Endocytosis in the mouse oocyte and its contribution to cAMP signaling during meiotic arrest. Reproduction. 2011;141:737-47 pubmed publisher
Park S, Kim K, Lindsey J, Dai Y, Heo H, Nguyen D, et al. A selective inhibitor of drp1, mdivi-1, increases retinal ganglion cell survival in acute ischemic mouse retina. Invest Ophthalmol Vis Sci. 2011;52:2837-43 pubmed publisher
Li Y, Xi D, Roman J, Huang Y, Gao W. Activation of glycogen synthase kinase-3 beta is required for hyperdopamine and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex. J Neurosci. 2009;29:15551-63 pubmed publisher
Proszynski T, Gingras J, Valdez G, Krzewski K, Sanes J. Podosomes are present in a postsynaptic apparatus and participate in its maturation. Proc Natl Acad Sci U S A. 2009;106:18373-8 pubmed publisher
Kolpak A, Jiang J, Guo D, Standley C, Bellve K, Fogarty K, et al. Negative guidance factor-induced macropinocytosis in the growth cone plays a critical role in repulsive axon turning. J Neurosci. 2009;29:10488-98 pubmed publisher
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
2897
SKU :
2897/10
product name :
Dynasore
description :
Non-competitive dynamin inhibitor
target :
Dynamin Inhibitors
unit size :
10 mg (also 50 mg)
category :
Small Molecules
purity :
99%
storage :
Store at -20°C
observed molecular weight :
322.32
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Dynasore is a non-competitive reversible inhibitor of dynamin 1, dynamin 2 and mitochondrial dynamin (Drp1) GTPase activity. Dynasore blocks endocytic pathways dependent on dynamin and inhibits cell spreading and migration of BSC1 cells. Dynasore attenuates motor symptoms in an animal model of Parkinson s disease and in a cellular model of Alzheimer s disease it reduces tau protein aggregation and internalization.
product keywords :
Non-competitive dynamin 1 2 mitochondrial Drp1 inhibitors inhibits Mitosis GTPases Mitosis Dynamin 2897,
extended description :
Non-competitive dynamin inhibitor
chemical name text :
3-Hydroxynaphthalene-2-carboxylic acid (3,4-dihydroxybenzylidene)hydrazide
formula :
C18H14N2O4
formula text :
C18H14N2O4
cas num :
304448-55-3
USD :
185
USD 2025 :
193 USD
product details :
Non-competitive dynamin inhibitor
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK