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company name :
Tocris Bioscience
product type :
chemical
product name :
HC 030031
catalog :
2896/10
quantity :
10 mg (also 50 mg)
price :
183 USD
more info or order :
citations: 31
Reference
Blaha I, López Oliva M, Martínez M, Recio P, Agis Torres A, Martinez A, et al. Bladder Dysfunction in an Obese Zucker Rat: The Role of TRPA1 Channels, Oxidative Stress, and Hydrogen Sulfide. Oxid Med Cell Longev. 2019;2019:5641645 pubmed publisher
Cheng R, Feng Y, Liu D, Wang Z, Zhang J, Chen L, et al. The role of Nav1.7 and methylglyoxal-mediated activation of TRPA1 in itch and hypoalgesia in a murine model of type 1 diabetes. Theranostics. 2019;9:4287-4307 pubmed publisher
Ko M, Ganzen L, Coşkun E, Mukadam A, Leung Y, van Rijn R. A critical evaluation of TRPA1-mediated locomotor behavior in zebrafish as a screening tool for novel anti-nociceptive drug discovery. Sci Rep. 2019;9:2430 pubmed publisher
GRIGGS R, Laird D, Donahue R, Fu W, Taylor B. Methylglyoxal Requires AC1 and TRPA1 to Produce Pain and Spinal Neuron Activation. Front Neurosci. 2017;11:679 pubmed publisher
Pan Y, Thapa D, Baldissera L, Argunhan F, Aubdool A, Brain S. Relevance of TRPA1 and TRPM8 channels as vascular sensors of cold in the cutaneous microvasculature. Pflugers Arch. 2018;470:779-786 pubmed publisher
Berrout J, Kyriakopoulou E, Moparthi L, Hogea A, Berrout L, Ivan C, et al. TRPA1-FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p. Nat Commun. 2017;8:947 pubmed publisher
Agarwal A, Wu P, Hughes E, Fukaya M, Tischfield M, Langseth A, et al. Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes. Neuron. 2017;93:587-605.e7 pubmed publisher
Hanlon K, Lozano Ondoua A, Umaretiya P, Symons Liguori A, Chandramouli A, Moy J, et al. Modulation of breast cancer cell viability by a cannabinoid receptor 2 agonist, JWH-015, is calcium dependent. Breast Cancer (Dove Med Press). 2016;8:59-71 pubmed publisher
Karaki S, Ishikawa J, Tomizawa Y, Kuwahara A. Effects of ?-viniferin, a dehydrodimer of resveratrol, on transepithelial active ion transport and ion permeability in the rat small and large intestinal mucosa. Physiol Rep. 2016;4: pubmed publisher
Fernandes E, Russell F, Alawi K, Sand C, Liang L, Salamon R, et al. Environmental cold exposure increases blood flow and affects pain sensitivity in the knee joints of CFA-induced arthritic mice in a TRPA1-dependent manner. Arthritis Res Ther. 2016;18:7 pubmed publisher
Wang X, Tian B, Huang Y, Peng X, Chen L, Li J, et al. Hydrogen sulfide-induced itch requires activation of Cav3.2 T-type calcium channel in mice. Sci Rep. 2015;5:16768 pubmed publisher
Mueller Tribbensee S, Karna M, Khalil M, Neurath M, Reeh P, Engel M. Differential Contribution of TRPA1, TRPV4 and TRPM8 to Colonic Nociception in Mice. PLoS ONE. 2015;10:e0128242 pubmed publisher
Ruparel S, Bendele M, Wallace A, Green D. Released lipids regulate transient receptor potential channel (TRP)-dependent oral cancer pain. Mol Pain. 2015;11:30 pubmed publisher
Shi H, Liu C, Ding L, Zheng Y, Fei X, Lu L, et al. Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction. World J Gastroenterol. 2015;21:4852-63 pubmed publisher
Paulsen C, Armache J, Gao Y, Cheng Y, Julius D. Structure of the TRPA1 ion channel suggests regulatory mechanisms. Nature. 2015;520:511-7 pubmed publisher
Sałat K, Filipek B. Antinociceptive activity of transient receptor potential channel TRPV1, TRPA1, and TRPM8 antagonists in neurogenic and neuropathic pain models in mice. J Zhejiang Univ Sci B. 2015;16:167-78 pubmed publisher
Liu B, Lin Y, Lee H, Ho C, Ruan T, Kou Y. Menthol suppresses laryngeal C-fiber hypersensitivity to cigarette smoke in a rat model of gastroesophageal reflux disease: the role of TRPM8. J Appl Physiol (1985). 2015;118:635-45 pubmed publisher
Bodkin J, Thakore P, Aubdool A, Liang L, Fernandes E, Nandi M, et al. Investigating the potential role of TRPA1 in locomotion and cardiovascular control during hypertension. Pharmacol Res Perspect. 2014;2:e00052 pubmed publisher
Aubdool A, Graepel R, Kodji X, Alawi K, Bodkin J, Srivastava S, et al. TRPA1 is essential for the vascular response to environmental cold exposure. Nat Commun. 2014;5:5732 pubmed publisher
Hsu C, Lin R, Lee L, Lin Y. Hydrogen sulfide induces hypersensitivity of rat capsaicin-sensitive lung vagal neurons: role of TRPA1 receptors. Am J Physiol Regul Integr Comp Physiol. 2013;305:R769-79 pubmed publisher
de la Roche J, Eberhardt M, Klinger A, Stanslowsky N, Wegner F, Koppert W, et al. The molecular basis for species-specific activation of human TRPA1 protein by protons involves poorly conserved residues within transmembrane domains 5 and 6. J Biol Chem. 2013;288:20280-92 pubmed publisher
Nesuashvili L, Hadley S, Bahia P, Taylor Clark T. Sensory nerve terminal mitochondrial dysfunction activates airway sensory nerves via transient receptor potential (TRP) channels. Mol Pharmacol. 2013;83:1007-19 pubmed publisher
Matsunami M, Miki T, Nishiura K, Hayashi Y, Okawa Y, Nishikawa H, et al. Involvement of the endogenous hydrogen sulfide/Ca(v) 3.2 T-type Ca2+ channel pathway in cystitis-related bladder pain in mice. Br J Pharmacol. 2012;167:917-28 pubmed publisher
Gregus A, Doolen S, Dumlao D, Buczynski M, Takasusuki T, Fitzsimmons B, et al. Spinal 12-lipoxygenase-derived hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors. Proc Natl Acad Sci U S A. 2012;109:6721-6 pubmed publisher
Liu T, Ji R. Oxidative stress induces itch via activation of transient receptor potential subtype ankyrin 1 in mice. Neurosci Bull. 2012;28:145-54 pubmed publisher
Izzo A, Capasso R, Aviello G, Borrelli F, Romano B, Piscitelli F, et al. Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice. Br J Pharmacol. 2012;166:1444-60 pubmed publisher
Kaji I, Yasuoka Y, Karaki S, Kuwahara A. Activation of TRPA1 by luminal stimuli induces EP4-mediated anion secretion in human and rat colon. Am J Physiol Gastrointest Liver Physiol. 2012;302:G690-701 pubmed publisher
Hirata H, Oshinsky M. Ocular dryness excites two classes of corneal afferent neurons implicated in basal tearing in rats: involvement of transient receptor potential channels. J Neurophysiol. 2012;107:1199-209 pubmed publisher
Capasso R, Aviello G, Romano B, Borrelli F, De Petrocellis L, Di Marzo V, et al. Modulation of mouse gastrointestinal motility by allyl isothiocyanate, a constituent of cruciferous vegetables (Brassicaceae): evidence for TRPA1-independent effects. Br J Pharmacol. 2012;165:1966-1977 pubmed publisher
Kaji I, Karaki S, Kuwahara A. Effects of luminal thymol on epithelial transport in human and rat colon. Am J Physiol Gastrointest Liver Physiol. 2011;300:G1132-43 pubmed publisher
Kunkler P, Ballard C, Oxford G, Hurley J. TRPA1 receptors mediate environmental irritant-induced meningeal vasodilatation. Pain. 2011;152:38-44 pubmed publisher
image
image 1 :
Tocris Bioscience 2896/10 image 1
Cat.No. 2896 - HC 030031 C18H21N5O3 CAS No. 349085-38-7
product information
brand :
Tocris
MasterCode :
2896
SKU :
2896/10
product name :
HC 030031
target :
TRPA1 Blockers
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
99%
observed molecular weight :
355.39
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
HC 030031 is a selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx (IC50 values are 6.2 and 5.3 u M respectively). Does not block currents mediated by TRPV1, TRPV3, TRPV4, hERG or NaV1.2 channels. Inhibits AITC- and formalin-induced flinching in vivo .
extended description :
Selective TRPA1 blocker
chemical name text :
2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide
formula :
C 18 H 21 N 5 O 3
formula text :
C18H21N5O3
cas num :
349085-38-7
USD :
183 USD
product details :
Selective TRPA1 blocker
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK