threo Ifenprodil hemitartrate | Tocris Bioscience 2892 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

threo Ifenprodil hemitartrate

catalog :

2892

quantity :

10 mg (also 50 mg)

price :

184 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Lassus B, Naudé J, Faure P, Guedin D, von Boxberg Y, Mannoury La Cour C, et al. Glutamatergic and dopaminergic modulation of cortico-striatal circuits probed by dynamic calcium imaging of networks reconstructed in microfluidic chips. Sci Rep. 2018;8:17461 pubmed publisher
Gasperini L, Meneghetti E, Pastore B, Benetti F, Legname G. Prion protein and copper cooperatively protect neurons by modulating NMDA receptor through S-nitrosylation. Antioxid Redox Signal. 2015;22:772-84 pubmed publisher

product information

brand :

Tocris

master code :

2892

SKU :

2892/10

product name :

threo Ifenprodil hemitartrate

description :

GluN2B-selective NMDA antagonist; also agonist

target :

NMDA Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

400.49

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent receptor agonist (Ki values are 59.1 and 2 nM for 1 and 2 receptors respectively) and GluN2B (formally NR2B) subunit-selective NMDA receptor antagonist (IC50 values are 0.22 and 324.8 M at GluN2B and GluN2A respectively). Displays ~8-fold reduced affinity at -adrenoceptors compared to Ifenprodil (Cat.No. 0545). Inhibits the hERG potassium channel (IC50 = 88 nM) and exhibits antiarrhythmic activity in vivo . . Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions .

catalog number base :

2892

product keywords :

NR2B selective NMDA antagonists receptors s sigma agonist ionotropic glutamate iGluR GluN2B Sigma-Related NMDA Receptors 2892,

extended description :

GluN2B-selective NMDA antagonist; also agonist

chemical name text :

(1S*,2S*)-threo-2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)-1-propanol hemitartrate

formula :

C 21 H 27 NO 2 . C 4 H 6 O 6

formula text :

C21H27NO2.?C4H6O6

2020 USD :

176

2021 USD :

184 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage