Ondansetron hydrochloride | Tocris Bioscience 2891/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Ondansetron hydrochloride

catalog :

2891/10

quantity :

10 mg (also 50 mg)

price :

144 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Spring S, Singh A, Zapata R, Chelikani P, Pezeshki A. Methionine Restriction Partly Recapitulates the Sympathetically Mediated Enhanced Energy Expenditure Induced by Total Amino Acid Restriction in Rats. Nutrients. 2019;11: pubmed publisher
Pezeshki A, Zapata R, Singh A, Yee N, Chelikani P. Low protein diets produce divergent effects on energy balance. Sci Rep. 2016;6:25145 pubmed publisher
Amorim D, Viisanen H, Wei H, Almeida A, Pertovaara A, Pinto Ribeiro F. Galanin-Mediated Behavioural Hyperalgesia from the Dorsomedial Nucleus of the Hypothalamus Involves Two Independent Descending Pronociceptive Pathways. PLoS ONE. 2015;10:e0142919 pubmed publisher
Jin Z, Lee G, Kim S, Park C, Park Y, Jin Y. Ginger and its pungent constituents non-competitively inhibit serotonin currents on visceral afferent neurons. Korean J Physiol Pharmacol. 2014;18:149-53 pubmed publisher
Capasso R, Aviello G, Romano B, Borrelli F, De Petrocellis L, Di Marzo V, et al. Modulation of mouse gastrointestinal motility by allyl isothiocyanate, a constituent of cruciferous vegetables (Brassicaceae): evidence for TRPA1-independent effects. Br J Pharmacol. 2012;165:1966-1977 pubmed publisher

product information

brand :

Tocris

catalog number base :

2891

SKU :

2891/10

product name :

Ondansetron hydrochloride

units size :

10 mg (also 50 mg)

description :

Selective 5-HT3 antagonist

target :

5-HT3 Receptor Antagonists

category :

Small Molecules

purity :

98%

observed molecular weight :

329.83

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Ondansetron hydrochloride is a selective 5-HT3 receptor antagonist (Ki = 6.16 nM). Also an inhibitor of human multidrug and toxin extrusion (MATE) transporter 1 (IC50 = 10-160 nM). Ondansetron blocks 5-HT-evoked transient inward currents (IC50 = 0.1 nM) in human recombinant h5-HT3A receptors. In an animal model of Parkinson s disease, Ondansetron reduces both the severity of dyskinesia and psychosis-like behaviors. Antiemetic; prevents emesis induced by cytotoxic drugs and radiation.

top caption :

Selective 5-HT3 antagonist

extended description :

Selective 5-HT3 antagonist

chemical name text :

1,2,3,9-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one hydrochloride

formula :

C18H19N3O.HCl

formula text :

C18H19N3O.HCl

cas num :

99614-01-4

USD :

144 USD

product details :

Selective 5-HT3 antagonist

alt names :

GR 38032

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage