BMS 299897 | Tocris Bioscience 2870/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BMS 299897

catalog :

2870/10

quantity :

10 mg

price :

167 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Liu C, Zhang C, Zhou Y, Wong W, Lee L, Ong W, et al. APP upregulation contributes to retinal ganglion cell degeneration via JNK3. Cell Death Differ. 2018;25:661-676 pubmed publisher
Pitt J, Wilcox K, Tortelli V, Diniz L, Oliveira M, Dobbins C, et al. Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound A? oligomers. Mol Biol Cell. 2017;28:2623-2636 pubmed publisher

product information

brand :

Tocris

master code :

2870

SKU :

2870/10

product name :

BMS 299897

description :

Potent -secretase inhibitor

target :

Secretase Inhibitors

category :

Small Molecules

unit sizes :

10 mg

purity :

98%

observed molecular weight :

511.94

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

BMS 299897 is an orally active, potent -secretase inhibitor (IC50 = 12 nM). Inhibits A 40 and A 42 formation in vitro (IC50 values are 7.4 and 7.9 nM respectively) and reduces A in the brain, plasma and cerebrospinal fluid in vivo . Exhibits no Notch toxicity. Brain penetrant.

extended description :

Potent -secretase inhibitor

chemical name text :

2-[(1R)-1-[[(4-Chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl-5-fluorobenzenebutanoic acid

formula :

C 24 H 21 ClF 3 NO 4 S

formula text :

C24H21ClF3NO4S

cas num :

290315-45-6

USD :

167 USD

product details :

Potent -secretase inhibitor

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage