Metformin hydrochloride | Tocris Bioscience 2864/100 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Metformin hydrochloride

catalog :

2864/100

quantity :

100 mg

price :

110 USD

more info or order :

Tocris Bioscience product webpage

citations: 18

Reference
Yang Y, Lu X, Liu N, Ma S, Zhang H, Zhang Z, et al. Metformin decelerates aging clock in male monkeys. Cell. 2024;187:6358-6378.e29 pubmed publisher
Bowling H, Bhattacharya A, Zhang G, Alam D, Lebowitz J, Bohm Levine N, et al. Altered steady state and activity-dependent de novo protein expression in fragile X syndrome. Nat Commun. 2019;10:1710 pubmed publisher
Westergard T, McAvoy K, Russell K, Wen X, Pang Y, Morris B, et al. Repeat-associated non-AUG translation in C9orf72-ALS/FTD is driven by neuronal excitation and stress. EMBO Mol Med. 2019;11: pubmed publisher
Marinangeli C, Didier S, Ahmed T, Caillerez R, Domise M, Laloux C, et al. AMP-Activated Protein Kinase Is Essential for the Maintenance of Energy Levels during Synaptic Activation. iScience. 2018;9:1-13 pubmed publisher
Xintaropoulou C, Ward C, Wise A, Queckborner S, Turnbull A, Michie C, et al. Expression of glycolytic enzymes in ovarian cancers and evaluation of the glycolytic pathway as a strategy for ovarian cancer treatment. BMC Cancer. 2018;18:636 pubmed publisher
Soliman G, Steenson S, Etekpo A. Effects of Metformin and a Mammalian Target of Rapamycin (mTOR) ATP-Competitive Inhibitor on Targeted Metabolomics in Pancreatic Cancer Cell Line. Metabolomics (Los Angel). 2016;6: pubmed publisher
Massey A. Modification of tumour cell metabolism modulates sensitivity to Chk1 inhibitor-induced DNA damage. Sci Rep. 2017;7:40778 pubmed publisher
Li Y, Zhang W, Chang L, Han Y, Sun L, Gong X, et al. Vitamin C alleviates aging defects in a stem cell model for Werner syndrome. Protein Cell. 2016;7:478-88 pubmed publisher
Domise M, Didier S, Marinangeli C, Zhao H, Chandakkar P, BuÃ©e L, et al. AMP-activated protein kinase modulates tau phosphorylation and tau pathology in vivo. Sci Rep. 2016;6:26758 pubmed publisher
Lin C, Tsai J, Chang C, Cheng J, Lin J. Development of telmisartan in the therapy of spinal cord injury: pre-clinical study in rats. Drug Des Devel Ther. 2015;9:4709-17 pubmed publisher
Naka K, Jomen Y, Ishihara K, Kim J, Ishimoto T, Bae E, et al. Dipeptide species regulate p38MAPK-Smad3 signalling to maintain chronic myelogenous leukaemia stem cells. Nat Commun. 2015;6:8039 pubmed publisher
Xintaropoulou C, Ward C, Wise A, Marston H, Turnbull A, Langdon S. A comparative analysis of inhibitors of the glycolysis pathway in breast and ovarian cancer cell line models. Oncotarget. 2015;6:25677-95 pubmed publisher
Yan H, Zhou H, Hu Y, Pham C. Suppression of experimental arthritis through AMP-activated protein kinase activation and autophagy modulation. J Rheum Dis Treat. 2015;1:5 pubmed
Mo J, Meng Z, Kim Y, Park H, Hansen C, Kim S, et al. Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway. Nat Cell Biol. 2015;17:500-10 pubmed publisher
Abdou H, Bergeron F, Tremblay J. A cell-autonomous molecular cascade initiated by AMP-activated protein kinase represses steroidogenesis. Mol Cell Biol. 2014;34:4257-71 pubmed publisher
Valente A, Irimpen A, Siebenlist U, Chandrasekar B. OxLDL induces endothelial dysfunction and death via TRAF3IP2: inhibition by HDL3 and AMPK activators. Free Radic Biol Med. 2014;70:117-28 pubmed publisher
Yung M, Chan D, Liu V, Yao K, Ngan H. Activation of AMPK inhibits cervical cancer cell growth through AKT/FOXO3a/FOXM1 signaling cascade. BMC Cancer. 2013;13:327 pubmed publisher
Edris B, Fletcher J, West R, van de Rijn M, Beck A. Comparative gene expression profiling of benign and malignant lesions reveals candidate therapeutic compounds for leiomyosarcoma. Sarcoma. 2012;2012:805614 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2864

SKU :

2864/100

product name :

Metformin hydrochloride

description :

Activator of LKB1/AMPK; antidiabetic agent

target :

AMPK Activators

unit size :

100 mg

category :

Small Molecules

storage :

Store at RT

observed molecular weight :

165.62

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Metformin hydrochloride is an antidiabetic agent; lowers plasma glucose levels and improves insulin sensitivity. Inhibits hepatic gluconeogenesis via activation of the LKB1/AMPK pathway. Displays antiproliferative effects in cancer cell lines via inhibition of mitochondrial complex I (MRC-1). Activates the aPKC-CBP pathway in neural precursors to promote neurogenesis. Activates autophagy. Identified by chemoinformatics as targeting human host proteins that interact with SARS-CoV-2. Metformin hydrochloride prevents brain atrophy, and slows the pace of aging across diverse tissues in animal studies.

product keywords :

activators LKB1/AMPK antidiabetic agent AMP-Activated Protein Kinases Enzyme Substrates mitochondrial complex I MRC1 COVID-19 SARS-CoV-2 severe acute respiratory syndrome Enzyme Substrates/ Activators AMPK Neural Stem Cells Autophagy COVID-19 Oxidative Phosphorylation Coronavirus 2864,

extended description :

Activator of LKB1/AMPK; antidiabetic agent

chemical name text :

N,N-Dimethylimidodicarbonimidic diamide hydrochloride

formula :

C4H11N5.HCl

formula text :

C4H11N5.HCl

cas num :

1115-70-4

USD :

105

USD 2025 :

110 USD

product details :

Activator of LKB1/AMPK; antidiabetic agent

more info or order :

Tocris Bioscience product webpage