PD 146176 | Tocris Bioscience 2850/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PD 146176

catalog :

2850/10

quantity :

10 mg (also 50 mg)

price :

190 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Ke Y, Zebda N, Oskolkova O, Afonyushkin T, Berdyshev E, Tian Y, et al. Anti-Inflammatory Effects of OxPAPC Involve Endothelial Cell-Mediated Generation of LXA4. Circ Res. 2017;121:244-257 pubmed publisher
Ruparel S, Henry M, AKOPIAN A, Patil M, Zeldin D, Roman L, et al. Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation. Pain. 2012;153:2031-9 pubmed publisher
Sordillo L, Weaver J, Cao Y, Corl C, Sylte M, Mullarky I. Enhanced 15-HPETE production during oxidant stress induces apoptosis of endothelial cells. Prostaglandins Other Lipid Mediat. 2005;76:19-34 pubmed

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2850

SKU :

2850/10

product name :

PD 146176

description :

Selective 15-lipoxygenase inhibitor

target :

Lipoxygenase Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at +4°C

observed molecular weight :

237.32

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PD 146176 is a specific, non-competitve 15-lipoxygenase (15-LOX) inhibitor (Ki = 197nM) that has no demonstrable effect on 5-LOX, 12-LOX, COX-1 or COX-2 (IC50 = 0.54 M for 15-LOX in rabbit reticulocytes). Lacks non-specific antioxidant properties and prevents atherogenesis via regulation of monocyte-macrophage enrichment in vivo .

product keywords :

Selective 15-lipoxygenase inhibitors inhibits Oxygenases Oxidases PD146176 15-LOX ferroptosis inhibitors inhibits Lipoxygenase Ferroptosis 2850,

extended description :

Selective 15-lipoxygenase inhibitor

chemical name text :

6,11-Dihydro[1]benzothiopyrano[4,3-b]indole

formula :

C15H11NS

formula text :

C15H11NS

cas num :

4079-26-9

USD :

188

USD 2025 :

190 USD

product details :

Selective 15-lipoxygenase inhibitor

more info or order :

Tocris Bioscience product webpage