SecinH3 | Tocris Bioscience 2849 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SecinH3

catalog :

2849

quantity :

10 mg (also 50 mg)

price :

244 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Abdul Salam V, Russomanno G, Chien Nien C, Mahomed A, Yates L, Wilkins M, et al. CLIC4/Arf6 Pathway. Circ Res. 2019;124:52-65 pubmed publisher
Ford C, NANS A, Boucrot E, Hayward R. Chlamydia exploits filopodial capture and a macropinocytosis-like pathway for host cell entry. PLoS Pathog. 2018;14:e1007051 pubmed publisher
Guichard A, Jain P, Moayeri M, Schwartz R, Chin S, Zhu L, et al. Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport. PLoS Pathog. 2017;13:e1006603 pubmed publisher
Risse P, Jo T, Suarez F, Hirota N, Tolloczko B, Ferraro P, et al. Interleukin-13 inhibits proliferation and enhances contractility of human airway smooth muscle cells without change in contractile phenotype. Am J Physiol Lung Cell Mol Physiol. 2011;300:L958-66 pubmed publisher

product information

brand :

Tocris

master code :

2849

SKU :

2849/10

product name :

SecinH3

description :

Sec7-specific GEF inhibitor; selective for cytohesin family

target :

ARF GTPase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

460.5

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Sec7-specific GEF inhibitor that displays selectivity for small GEFs of the cytohesin family (IC50 values are 2.4, 5.4, 5.4, 5.6, 5.6, 65 and 100 u M for hCyh2, hCyh1, mCyh3, hCyh3, drosophila steppke, yGea2-S7 and hEFA6-S7 respectively). Inhibits insulin signaling via inhibition of insulin receptor substrate protein (IRS) phosphorylation.

catalog number base :

2849

product keywords :

Sec7-specific GEF inhibitors inhibits cytohesins hCyh2 hCyh1 mCyh3 hCyh3 drosophila steppke G Proteins Small Arf 2849, ARF, ADP ribosylation factor, GTP ase,

extended description :

Sec7-specific GEF inhibitor; selective for cytohesin family

chemical name text :

N-[4-[5-(1,3-Benzodioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl]phenyl]-2-(phenylthio)acetamide

formula :

C 24 H 20 N 4 O 4 S

formula text :

C24H20N4O4S

cas num :

853625-60-2

2020 USD :

236

2021 USD :

244 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage