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company name :
Tocris Bioscience
product type :
chemical
product name :
Mecamylamine hydrochloride
catalog :
2843/10
quantity :
10 mg (also 50 mg)
price :
132 USD
more info or order :
citations: 22
Reference
Pujala A, Koyama M. Chronology-based architecture of descending circuits that underlie the development of locomotor repertoire after birth. elife. 2019;8: pubmed publisher
Morris M, Shaw A, Lambert M, Perry H, Lowenstein E, Valenzuela D, et al. Developmental nicotine exposure affects larval brain size and the adult dopaminergic system of Drosophila melanogaster. BMC Dev Biol. 2018;18:13 pubmed publisher
Lozovaya N, Eftekhari S, Cloarec R, Gouty Colomer L, Dufour A, Riffault B, et al. GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease. Nat Commun. 2018;9:1422 pubmed publisher
Takahashi T, Shiraishi A, Murata J. The Coordinated Activities of nAChR and Wnt Signaling Regulate Intestinal Stem Cell Function in Mice. Int J Mol Sci. 2018;19: pubmed publisher
Assous M, Kaminer J, Shah F, Garg A, Koos T, Tepper J. Differential processing of thalamic information via distinct striatal interneuron circuits. Nat Commun. 2017;8:15860 pubmed publisher
Sternfeld M, Hinckley C, Moore N, Pankratz M, Hilde K, Driscoll S, et al. Speed and segmentation control mechanisms characterized in rhythmically-active circuits created from spinal neurons produced from genetically-tagged embryonic stem cells. elife. 2017;6: pubmed publisher
Mamaligas A, Cai Y, Ford C. Nicotinic and opioid receptor regulation of striatal dopamine D2-receptor mediated transmission. Sci Rep. 2016;6:37834 pubmed publisher
Herman A, Ortiz Guzman J, Kochukov M, Herman I, Quast K, Patel J, et al. A cholinergic basal forebrain feeding circuit modulates appetite suppression. Nature. 2016;538:253-256 pubmed publisher
Boo H, Min H, Jang H, Yun H, Smith J, Jin Q, et al. The tobacco-specific carcinogen-operated calcium channel promotes lung tumorigenesis via IGF2 exocytosis in lung epithelial cells. Nat Commun. 2016;7:12961 pubmed publisher
Kam K, Duffy Ã, Moretto J, Lafrancois J, Scharfman H. Interictal spikes during sleep are an early defect in the Tg2576 mouse model of β-amyloid neuropathology. Sci Rep. 2016;6:20119 pubmed publisher
Stouffer M, Woods C, Patel J, Lee C, Witkovsky P, Bao L, et al. Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward. Nat Commun. 2015;6:8543 pubmed publisher
Falgairolle M, O Donovan M. Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons. PLoS ONE. 2015;10:e0131430 pubmed publisher
Shin J, Adrover M, Wess J, Alvarez V. Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens. Proc Natl Acad Sci U S A. 2015;112:8124-9 pubmed publisher
Dannenberg H, Pabst M, Braganza O, Schoch S, Niediek J, Bayraktar M, et al. Synergy of direct and indirect cholinergic septo-hippocampal pathways coordinates firing in hippocampal networks. J Neurosci. 2015;35:8394-410 pubmed publisher
Liu S, Shao Z, Puche A, Wachowiak M, Rothermel M, Shipley M. Muscarinic receptors modulate dendrodendritic inhibitory synapses to sculpt glomerular output. J Neurosci. 2015;35:5680-92 pubmed publisher
Saunders A, Granger A, Sabatini B. Corelease of acetylcholine and GABA from cholinergic forebrain neurons. elife. 2015;4: pubmed publisher
Elgueta C, Vielma A, Palacios A, Schmachtenberg O. Acetylcholine induces GABA release onto rod bipolar cells through heteromeric nicotinic receptors expressed in A17 amacrine cells. Front Cell Neurosci. 2015;9:6 pubmed publisher
Bryant A, Goddard C, Huguenard J, Knudsen E. Cholinergic control of gamma power in the midbrain spatial attention network. J Neurosci. 2015;35:761-75 pubmed publisher
Leão R, Targino Z, Colom L, Fisahn A. Interconnection and synchronization of neuronal populations in the mouse medial septum/diagonal band of Broca. J Neurophysiol. 2015;113:971-80 pubmed publisher
Costello M, Reynaga D, Mojica C, Zaveri N, Belluzzi J, Leslie F. Comparison of the reinforcing properties of nicotine and cigarette smoke extract in rats. Neuropsychopharmacology. 2014;39:1843-51 pubmed publisher
Zhang J, Xue F, Whiteaker P, Li C, Wu W, Shen B, et al. Desensitization of alpha7 nicotinic receptor is governed by coupling strength relative to gate tightness. J Biol Chem. 2011;286:25331-40 pubmed publisher
Higley M, Gittis A, Oldenburg I, Balthasar N, Seal R, Edwards R, et al. Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum. PLoS ONE. 2011;6:e19155 pubmed publisher
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
2843
SKU :
2843/10
product name :
Mecamylamine hydrochloride
description :
Non-competitive nAChR antagonist
target :
Additional Nicotinic Receptor Antagonists
unit size :
10 mg (also 50 mg)
category :
Small Molecules
storage :
Desiccate at RT
observed molecular weight :
203.75
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Mecamylamine hydrochloride is a non-competitive nicotinic acetylcholine receptor antagonist. Displays antidepressant-like effects in mice.
product keywords :
Non-competitive nicotinic receptors antagonists Acetylcholine Non-Selective Subtypes nAChR 826-39-1 Nicotinic Receptors (Non-selective) 2843,
extended description :
Non-competitive nAChR antagonist
chemical name text :
(1R,2S,4S)-rel-N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride
formula :
C11H21N.HCl
formula text :
C11H21N.HCl
cas num :
110691-49-1
USD :
128
USD 2025 :
132 USD
product details :
Non-competitive nAChR antagonist
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK