AICAR | Tocris Bioscience 2840 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AICAR

catalog :

2840

quantity :

50 mg

price :

126 USD

more info or order :

Tocris Bioscience product webpage

citations: 20

Reference
Hu Q, Li L, Zou X, Xu L, Yi P. Berberine Attenuated Proliferation, Invasion and Migration by Targeting the AMPK/HNF4α/WNT5A Pathway in Gastric Carcinoma. Front Pharmacol. 2018;9:1150 pubmed publisher
Marinangeli C, Didier S, Ahmed T, Caillerez R, Domise M, Laloux C, et al. AMP-Activated Protein Kinase Is Essential for the Maintenance of Energy Levels during Synaptic Activation. iScience. 2018;9:1-13 pubmed publisher
Sen N, Cross A, Lorenzi P, Khan J, Gryder B, Kim S, et al. EWS-FLI1 reprograms the metabolism of Ewing sarcoma cells via positive regulation of glutamine import and serine-glycine biosynthesis. Mol Carcinog. 2018;57:1342-1357 pubmed publisher
Hashiguchi H, Sheng Z, Routh V, Gerzanich V, Simard J, Bryan J. Direct versus indirect actions of ghrelin on hypothalamic NPY neurons. PLoS ONE. 2017;12:e0184261 pubmed publisher
Kim S, Neuendorff N, Chapkin R, Earnest D. Role of Inflammatory Signaling in the Differential Effects of Saturated and Poly-unsaturated Fatty Acids on Peripheral Circadian Clocks. EBioMedicine. 2016;7:100-11 pubmed publisher
Mo J, Meng Z, Kim Y, Park H, Hansen C, Kim S, et al. Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway. Nat Cell Biol. 2015;17:500-10 pubmed publisher
Hassan W, Rongyin G, Daoud A, Ding L, Wang L, Liu J, et al. Reduced oxidative stress contributes to the lipid lowering effects of isoquercitrin in free fatty acids induced hepatocytes. Oxid Med Cell Longev. 2014;2014:313602 pubmed publisher
Abdou H, Bergeron F, Tremblay J. A cell-autonomous molecular cascade initiated by AMP-activated protein kinase represses steroidogenesis. Mol Cell Biol. 2014;34:4257-71 pubmed publisher
Jurmeister S, Ramos Montoya A, Neal D, Fryer L. Transcriptomic analysis reveals inhibition of androgen receptor activity by AMPK in prostate cancer cells. Oncotarget. 2014;5:3785-99 pubmed
Abdulhag U, Soiferman D, Schueler Furman O, Miller C, Shaag A, Elpeleg O, et al. Mitochondrial complex IV deficiency, caused by mutated COX6B1, is associated with encephalomyopathy, hydrocephalus and cardiomyopathy. Eur J Hum Genet. 2015;23:159-64 pubmed publisher
Mohseni M, Sun J, Lau A, Curtis S, Goldsmith J, Fox V, et al. A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway. Nat Cell Biol. 2014;16:108-17 pubmed publisher
Mounier R, Theret M, Arnold L, Cuvellier S, Bultot L, Göransson O, et al. AMPK?1 regulates macrophage skewing at the time of resolution of inflammation during skeletal muscle regeneration. Cell Metab. 2013;18:251-64 pubmed publisher
Hutchins B, Klenke U, Wray S. Calcium release-dependent actin flow in the leading process mediates axophilic migration. J Neurosci. 2013;33:11361-71 pubmed publisher
Yung M, Chan D, Liu V, Yao K, Ngan H. Activation of AMPK inhibits cervical cancer cell growth through AKT/FOXO3a/FOXM1 signaling cascade. BMC Cancer. 2013;13:327 pubmed publisher
Seto S, Au A, Poon C, Zhang Q, Li R, Yeung J, et al. Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes. PLoS ONE. 2013;8:e66404 pubmed publisher
Fong J, Le Nihouannen D, Tiedemann K, Sadvakassova G, Barralet J, Komarova S. Moderate excess of pyruvate augments osteoclastogenesis. Biol Open. 2013;2:387-95 pubmed publisher
Taub D, Hesdorffer C, Ferrucci L, Madara K, Schwartz J, Goetzl E. Distinct energy requirements for human memory CD4 T-cell homeostatic functions. FASEB J. 2013;27:342-9 pubmed publisher
Terry L, Vastag L, Rabinowitz J, Shenk T. Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection. Proc Natl Acad Sci U S A. 2012;109:3071-6 pubmed publisher
Bumpus N, Johnson E. 5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated pro. J Pharmacol Exp Ther. 2011;339:886-95 pubmed publisher
Creighton J, Jian M, SAYNER S, Alexeyev M, Insel P. Adenosine monophosphate-activated kinase alpha1 promotes endothelial barrier repair. FASEB J. 2011;25:3356-65 pubmed publisher

product information

brand :

Tocris

master code :

2840

SKU :

2840/50

product name :

AICAR

description :

AMPK activator

target :

AMPK Activators

category :

Small Molecules

unit size :

50 mg

purity :

99%

observed molecular weight :

258.23

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. Promotes osteogenic differentiation of hAMSCs and BM-MSCs in vitro .

catalog number base :

2840

product keywords :

AMPK activators AMP-Activated Protein Kinases Enzyme Substrates Enzyme Substrates/ Activators AMPK Osteogenic Stem Cells Mesenchymal Stem Cells 2840,

extended description :

AMPK activator

chemical name text :

N1-( -D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide

formula :

C 9 H 14 N 4 O 5

formula text :

C9H14N4O5

cas num :

2627-69-2

2020 USD :

121

2021 USD :

126 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage