product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
AICAR
catalog :
2840/50
quantity :
50 mg
price :
168 USD
more info or order :
citations: 24
Reference
Hu Q, Li L, Zou X, Xu L, Yi P. Berberine Attenuated Proliferation, Invasion and Migration by Targeting the AMPK/HNF4α/WNT5A Pathway in Gastric Carcinoma. Front Pharmacol. 2018;9:1150 pubmed publisher
Marinangeli C, Didier S, Ahmed T, Caillerez R, Domise M, Laloux C, et al. AMP-Activated Protein Kinase Is Essential for the Maintenance of Energy Levels during Synaptic Activation. iScience. 2018;9:1-13 pubmed publisher
Sen N, Cross A, Lorenzi P, Khan J, Gryder B, Kim S, et al. EWS-FLI1 reprograms the metabolism of Ewing sarcoma cells via positive regulation of glutamine import and serine-glycine biosynthesis. Mol Carcinog. 2018;57:1342-1357 pubmed publisher
Hashiguchi H, Sheng Z, Routh V, Gerzanich V, Simard J, Bryan J. Direct versus indirect actions of ghrelin on hypothalamic NPY neurons. PLoS ONE. 2017;12:e0184261 pubmed publisher
Cameron A, Morrison V, Levin D, Mohan M, Forteath C, Beall C, et al. Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status. Circ Res. 2016;119:652-65 pubmed publisher
Kim S, Neuendorff N, Chapkin R, Earnest D. Role of Inflammatory Signaling in the Differential Effects of Saturated and Poly-unsaturated Fatty Acids on Peripheral Circadian Clocks. EBioMedicine. 2016;7:100-11 pubmed publisher
Domise M, Didier S, Marinangeli C, Zhao H, Chandakkar P, Buée L, et al. AMP-activated protein kinase modulates tau phosphorylation and tau pathology in vivo. Sci Rep. 2016;6:26758 pubmed publisher
Mo J, Meng Z, Kim Y, Park H, Hansen C, Kim S, et al. Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway. Nat Cell Biol. 2015;17:500-10 pubmed publisher
Hassan W, Rongyin G, Daoud A, Ding L, Wang L, Liu J, et al. Reduced oxidative stress contributes to the lipid lowering effects of isoquercitrin in free fatty acids induced hepatocytes. Oxid Med Cell Longev. 2014;2014:313602 pubmed publisher
Abdou H, Bergeron F, Tremblay J. A cell-autonomous molecular cascade initiated by AMP-activated protein kinase represses steroidogenesis. Mol Cell Biol. 2014;34:4257-71 pubmed publisher
Jurmeister S, Ramos Montoya A, Neal D, Fryer L. Transcriptomic analysis reveals inhibition of androgen receptor activity by AMPK in prostate cancer cells. Oncotarget. 2014;5:3785-99 pubmed
Biesemann N, Mendler L, Wietelmann A, Hermann S, Schäfers M, Kruger M, et al. Myostatin regulates energy homeostasis in the heart and prevents heart failure. Circ Res. 2014;115:296-310 pubmed publisher
Abdulhag U, Soiferman D, Schueler Furman O, Miller C, Shaag A, Elpeleg O, et al. Mitochondrial complex IV deficiency, caused by mutated COX6B1, is associated with encephalomyopathy, hydrocephalus and cardiomyopathy. Eur J Hum Genet. 2015;23:159-64 pubmed publisher
Figarola J, Singhal P, Rahbar S, Gugiu B, Awasthi S, Singhal S. COH-SR4 reduces body weight, improves glycemic control and prevents hepatic steatosis in high fat diet-induced obese mice. PLoS ONE. 2013;8:e83801 pubmed publisher
Mohseni M, Sun J, Lau A, Curtis S, Goldsmith J, Fox V, et al. A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway. Nat Cell Biol. 2014;16:108-17 pubmed publisher
Mounier R, Theret M, Arnold L, Cuvellier S, Bultot L, Göransson O, et al. AMPK?1 regulates macrophage skewing at the time of resolution of inflammation during skeletal muscle regeneration. Cell Metab. 2013;18:251-64 pubmed publisher
Hutchins B, Klenke U, Wray S. Calcium release-dependent actin flow in the leading process mediates axophilic migration. J Neurosci. 2013;33:11361-71 pubmed publisher
Yung M, Chan D, Liu V, Yao K, Ngan H. Activation of AMPK inhibits cervical cancer cell growth through AKT/FOXO3a/FOXM1 signaling cascade. BMC Cancer. 2013;13:327 pubmed publisher
Seto S, Au A, Poon C, Zhang Q, Li R, Yeung J, et al. Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes. PLoS ONE. 2013;8:e66404 pubmed publisher
Fong J, Le Nihouannen D, Tiedemann K, Sadvakassova G, Barralet J, Komarova S. Moderate excess of pyruvate augments osteoclastogenesis. Biol Open. 2013;2:387-95 pubmed publisher
Taub D, Hesdorffer C, Ferrucci L, Madara K, Schwartz J, Goetzl E. Distinct energy requirements for human memory CD4 T-cell homeostatic functions. FASEB J. 2013;27:342-9 pubmed publisher
Terry L, Vastag L, Rabinowitz J, Shenk T. Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection. Proc Natl Acad Sci U S A. 2012;109:3071-6 pubmed publisher
Bumpus N, Johnson E. 5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated pro. J Pharmacol Exp Ther. 2011;339:886-95 pubmed publisher
Creighton J, Jian M, SAYNER S, Alexeyev M, Insel P. Adenosine monophosphate-activated kinase alpha1 promotes endothelial barrier repair. FASEB J. 2011;25:3356-65 pubmed publisher
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
2840
SKU :
2840/50
product name :
AICAR
description :
AMPK activator
target :
AMPK Activators
unit size :
50 mg
category :
Small Molecules
purity :
99%
storage :
Store at -20°C
observed molecular weight :
258.23
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
AICAR is a cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. Promotes osteogenic differentiation of hAMSCs and BM-MSCs in vitro .
product keywords :
AMPK activators AMP-Activated Protein Kinases Enzyme Substrates Enzyme Substrates/ Activators AMPK Osteogenic Stem Cells Mesenchymal Stem Cells 2840,
extended description :
AMPK activator
chemical name text :
N1-( -D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide
formula :
C9H14N4O5
formula text :
C9H14N4O5
cas num :
2627-69-2
USD :
161
USD 2025 :
168 USD
product details :
AMPK activator
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK