Withaferin A | Tocris Bioscience 2816/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Withaferin A

catalog :

2816/1

quantity :

1 mg

price :

189 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Ryals M, Morell R, Martin D, Boger E, Wu P, Raible D, et al. The Inner Ear Heat Shock Transcriptional Signature Identifies Compounds That Protect Against Aminoglycoside Ototoxicity. Front Cell Neurosci. 2018;12:445 pubmed publisher
Andersson P, Yang Y, Hosaka K, Zhang Y, Fischer C, Braun H, et al. Molecular mechanisms of IL-33-mediated stromal interactions in cancer metastasis. JCI Insight. 2018;3: pubmed publisher
Hatzold J, Beleggia F, Herzig H, Altmuller J, Nurnberg P, Bloch W, et al. Tumor suppression in basal keratinocytes via dual non-cell-autonomous functions of a Na,K-ATPase beta subunit. elife. 2016;5: pubmed publisher
Yang Y, Andersson P, Hosaka K, Zhang Y, Cao R, Iwamoto H, et al. The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages. Nat Commun. 2016;7:11385 pubmed publisher
Martorana F, Guidotti G, Brambilla L, Rossi D. Withaferin A Inhibits Nuclear Factor-ÎºB-Dependent Pro-Inflammatory and Stress Response Pathways in the Astrocytes. Neural Plast. 2015;2015:381964 pubmed publisher
Trendelenburg A, Meyer A, Jacobi C, Feige J, Glass D. TAK-1/p38/nNF?B signaling inhibits myoblast differentiation by increasing levels of Activin A. Skelet Muscle. 2012;2:3 pubmed publisher
Yadav V, Sung B, Prasad S, Kannappan R, Cho S, Liu M, et al. Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor. J Mol Med (Berl). 2010;88:1243-53 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2816

SKU :

2816/1

product name :

Withaferin A

description :

Inhibits NF- B activation

target :

NFkB/IkB Inhibitors

unit size :

1 mg

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

470.6

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Withaferin A is a steroid lactone that displays anti-inflammatory, antitumor and antiangiogenic activity. Withaferin A inhibits endothelial cells (HUVEC) sprouting in vitro (IC50 = 12 nM) and in vivo , prevents NF- B activation by inhibiting activation of IKK and inhibits chymotrypsin-like activity of the 20S proteasome. In an animal model of Huntington s disease (HD), Withaferin A delays disease progression and increases lifespan; in a cellular model it suppresses aggregation of mutant huntingtin, activates HSF1 and induces Hsp70 chaperone expression.

product keywords :

inhibitors inhibits NF- B NF-kappaB NF-kB activation Nuclear Factor Kappa B Cytokine Signaling Signalling Transcription Factors WithaferinA NF-kB/IkB 2816,

extended description :

Inhibits NF- B activation

chemical name text :

(4 ,5 ,6 ,22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oic acid -lactone

formula :

C28H38O6

formula text :

C28H38O6

cas num :

5119-48-2

USD :

187

USD 2025 :

189 USD

product details :

Inhibits NF- B activation

more info or order :

Tocris Bioscience product webpage