Valproic acid, sodium salt | Tocris Bioscience 2815/100 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Valproic acid, sodium salt

catalog :

2815/100

quantity :

100 mg

price :

93 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Caires JÃºnior L, Goulart E, Melo U, Araujo B, Alvizi L, Soares Schanoski A, et al. Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells. Nat Commun. 2018;9:475 pubmed publisher
Zeltner N, Fattahi F, Dubois N, Saurat N, Lafaille F, Shang L, et al. Capturing the biology of disease severity in a PSC-based model of familial dysautonomia. Nat Med. 2016;22:1421-1427 pubmed publisher
Chen X, Cao H, Saraf A, Zweifel L, Storm D. Overexpression of the type 1 adenylyl cyclase in the forebrain leads to deficits of behavioral inhibition. J Neurosci. 2015;35:339-51 pubmed publisher
Lee R, Kim I, Han N, Yun S, Park K, Yoo K. Real-time discrimination between proliferation and neuronal and astroglial differentiation of human neural stem cells. Sci Rep. 2014;4:6319 pubmed publisher
Wang J, Elahi A, Ajidahun A, Clark W, Hernandez J, Achille A, et al. The interplay between histone deacetylases and c-Myc in the transcriptional suppression of HPP1 in colon cancer. Cancer Biol Ther. 2014;15:1198-207 pubmed publisher

product information

brand :

Tocris

catalog number base :

2815

SKU :

2815/100

product name :

Valproic acid, sodium salt

units size :

100 mg

description :

Histone deacetylase inhibitor

target :

Class I Histone Deacetylases Inhibitors

category :

Small Molecules

observed molecular weight :

166.19

url print :

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review stars :

details of functionality :

Valproic acid, sodium salt is a histone deacetylase inhibitor (IC50 = 400 u M) that exhibits anticancer, anti-inflammatory and neuroprotective effects. Displays anticonvulsive activity via an increase in GABA levels and decreases A production in animal models of Alzheimer s disease. Also attenuates NMDA-mediated excitation, blocks voltage-gated Na+ channels and modulates firing of neurons. Enables induction of pluripotent stem cells from somatic cells by Oct4 and Sox2. Can induce autophagy by inhibiting inositol synthesis. Identified by chemoinformatics as targeting human host proteins that interact with SARS-CoV-2. Enables induction of Chemically Induced Pluripotent Stem Cells (CiPSCs) from mouse embryonic fibroblasts (see our protocol below). . For more information about how Valproic acid, sodium salt may be used, see our protocol: Highly Efficient Generation of Chemically Induced Pluripotent Stem Cells (CiPSCs) from Mouse Embryonic Fibroblasts (MEFs).

top caption :

Histone deacetylase inhibitor

extended description :

Histone deacetylase inhibitor

chemical name text :

Sodium 2-propylpentanoate

formula :

C8H15NaO2

formula text :

C8H15NaO2

cas num :

1069-66-5

USD :

93 USD

product details :

Histone deacetylase inhibitor

alt names :

VPA,Sodium Valproate

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage