PI 828 | Tocris Bioscience 2814/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PI 828

catalog :

2814/1

quantity :

1 mg

price :

119 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Mahfouz N, Tahtouh R, Alaaeddine N, El Hajj J, Sarkis R, Hachem R, et al. Gastrointestinal cancer cells treatment with bevacizumab activates a VEGF autoregulatory mechanism involving telomerase catalytic subunit hTERT via PI3K-AKT, HIF-1? and VEGF receptors. PLoS ONE. 2017;12:e0179202 pubmed publisher
Liddell J, Lehtonen S, Duncan C, Keksa Goldsteine V, Levonen A, Goldsteins G, et al. Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes. J Neuroinflammation. 2016;13:49 pubmed publisher
Rogers S, Gahring L. Upregulation of Nicotinic Acetylcholine Receptor alph4+beta2 through a Ligand-Independent PI3Kbeta Mechanism That Is Enhanced by TNFalpha and the Jak2/p38Mapk Pathways. PLoS ONE. 2015;10:e0143319 pubmed publisher
Moser R, Xu C, Kao M, Annis J, Lerma L, Schaupp C, et al. Functional kinomics identifies candidate therapeutic targets in head and neck cancer. Clin Cancer Res. 2014;20:4274-88 pubmed publisher
Park M, Ohana E, Choi S, Lee M, Park J, Muallem S. Multiple roles of the SO4(2-)/Cl-/OH- exchanger protein Slc26a2 in chondrocyte functions. J Biol Chem. 2014;289:1993-2001 pubmed publisher
Grassin Delyle S, Abrial C, Fayad Kobeissi S, Brollo M, Faisy C, Alvarez J, et al. The expression and relaxant effect of bitter taste receptors in human bronchi. Respir Res. 2013;14:134 pubmed publisher
Kulkarni A, Roy B, Rao P, Wyant G, Mahmoud A, Ramachandran M, et al. Supramolecular nanoparticles that target phosphoinositide-3-kinase overcome insulin resistance and exert pronounced antitumor efficacy. Cancer Res. 2013;73:6987-97 pubmed publisher
Li J, Kanju P, Patterson M, Chew W, Cho S, Gilmour I, et al. TRPV4-mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles. Environ Health Perspect. 2011;119:784-93 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2814

SKU :

2814/1

product name :

PI 828

description :

PI 3-kinase inhibitor, more potent than LY 294002 (Cat. No. 1130)

target :

PI 3-Kinase Inhibitors

unit size :

1 mg

category :

Small Molecules

purity :

98%

storage :

Store at +4°C

observed molecular weight :

322.36

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PI 828 is a PI 3-Kinase inhibitor (IC50 values are 0.098, 0.183, 0.227 and 1.967 u M for p110 , p110 , p110 and p110 respectively) that displays higher potency than LY 294002 (Cat No. 1130). Can be immobilized onto a solid phase.

product keywords :

PI 3-kinase inhibitors inhibits potent LY 294002 PI3K Phosphoinositide 3-Kinases PI828 PI 3-Kinase Inositol Lipids 2814,

extended description :

PI 3-kinase inhibitor, more potent than LY 294002 (Cat. No. 1130)

chemical name text :

2-(4-Morpholinyl)-8-(4-aminopheny)l-4H-1-benzopyran-4-one

formula :

C19H18N2O3

formula text :

C19H18N2O3

cas num :

942289-87-4

USD :

132

USD 2025 :

119 USD

product details :

PI 3-kinase inhibitor, more potent than LY 294002 (Cat. No. 1130)

more info or order :

Tocris Bioscience product webpage