Stattic | Tocris Bioscience 2798 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Stattic

catalog :

2798

quantity :

10 mg (also 50 mg)

price :

87 USD

more info or order :

Tocris Bioscience product webpage

citations: 18

Reference
Fan P, Tyagi A, Agboke F, Mathur R, Pokharel N, Jordan V. Modulation of nuclear factor-kappa B activation by the endoplasmic reticulum stress sensor PERK to mediate estrogen-induced apoptosis in breast cancer cells. Cell Death Discov. 2018;4:15 pubmed publisher
Petes C, Mariani M, Yang Y, Grandvaux N, Gee K. Interleukin (IL)-6 Inhibits IL-27- and IL-30-Mediated Inflammatory Responses in Human Monocytes. Front Immunol. 2018;9:256 pubmed publisher
Dong J, An X, Zhong H, Wang Y, Shang J, Zhou J. Interleukin-22 participates in the inflammatory process of vitiligo. Oncotarget. 2017;8:109161-109174 pubmed publisher
Banerjee K, Keasey M, Razskazovskiy V, Visavadiya N, Jia C, Hagg T. Reduced FAK-STAT3 signaling contributes to ER stress-induced mitochondrial dysfunction and death in endothelial cells. Cell Signal. 2017;36:154-162 pubmed publisher
Visavadiya N, Keasey M, Razskazovskiy V, Banerjee K, Jia C, Lovins C, et al. Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3. Cell Commun Signal. 2016;14:32 pubmed
Peda J, Salah S, Wallace D, Fields P, Grantham C, Fields T, et al. Autocrine IL-10 activation of the STAT3 pathway is required for pathological macrophage differentiation in polycystic kidney disease. Dis Model Mech. 2016;9:1051-61 pubmed publisher
Ko H, Park B, Choi S, Kang H, Kim A, Kim H, et al. STAT3 and ERK Signaling Pathways Are Implicated in the Invasion Activity by Oncostatin M through Induction of Matrix Metalloproteinases 2 and 9. Yonsei Med J. 2016;57:761-8 pubmed publisher
Okada S, Han S, Patel E, Yang L, Chang L. STAT3 signaling contributes to the high effector activities of interleukin-15-derived dendritic cells. Immunol Cell Biol. 2015;93:461-71 pubmed publisher
Conner C, Ackerman K, Lahne M, Hobgood J, Hyde D. Repressing notch signaling and expressing TNFÎ± are sufficient to mimic retinal regeneration by inducing MÃ¼ller glial proliferation to generate committed progenitor cells. J Neurosci. 2014;34:14403-19 pubmed publisher
Shravah J, Wang B, Pavlovic M, Kumar U, Chen D, Luo H, et al. Propofol mediates signal transducer and activator of transcription 3 activation and crosstalk with phosphoinositide 3-kinase/AKT. JAKSTAT. 2014;3:e29554 pubmed publisher
Natarajan R, Singal V, Benes R, Gao J, Chan H, Chen H, et al. STAT3 modulation to enhance motor neuron differentiation in human neural stem cells. PLoS ONE. 2014;9:e100405 pubmed publisher
Liu X, Tian Y, Lu N, Gin T, Cheng C, Chan M. Stat3 inhibition attenuates mechanical allodynia through transcriptional regulation of chemokine expression in spinal astrocytes. PLoS ONE. 2013;8:e75804 pubmed publisher
Haynes T, Luz Madrigal A, Reis E, Echeverri Ruiz N, Grajales Esquivel E, Tzekou A, et al. Complement anaphylatoxin C3a is a potent inducer of embryonic chick retina regeneration. Nat Commun. 2013;4:2312 pubmed publisher
Price R, Song J, Bingmer K, Kim T, Yi J, Nowicki M, et al. Cytomegalovirus contributes to glioblastoma in the context of tumor suppressor mutations. Cancer Res. 2013;73:3441-50 pubmed publisher
Keasey M, Kang S, Lovins C, Hagg T. Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression. Cell Commun Signal. 2013;11:35 pubmed publisher
Hodge L, Ziesmer S, Yang Z, Secreto F, Gertz M, Novak A, et al. IL-21 in the bone marrow microenvironment contributes to IgM secretion and proliferation of malignant cells in Waldenstrom macroglobulinemia. Blood. 2012;120:3774-82 pubmed publisher
Katz E, Sims A, Sproul D, Caldwell H, Dixon M, Meehan R, et al. Targeting of Rac GTPases blocks the spread of intact human breast cancer. Oncotarget. 2012;3:608-19 pubmed
Beales I, Ogunwobi O. Glycine-extended gastrin inhibits apoptosis in Barrett's oesophageal and oesophageal adenocarcinoma cells through JAK2/STAT3 activation. J Mol Endocrinol. 2009;42:305-18 pubmed publisher

product information

brand :

Tocris

master code :

2798

SKU :

2798/10

product name :

Stattic

description :

Selective STAT3 inhibitor

target :

STAT Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

211.19

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Small molecule inhibitor of STAT3. Inhibits binding of tyrosine-phosphorylated peptide motifs to STAT3 SH2 domain and inhibits STAT3 activation, dimerization and nuclear translocation. Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. Induces apoptosis in STAT3-dependent cancer cell lines.

catalog number base :

2798

product keywords :

Selective STAT3 inhibitors inhibits STAT Transcription Factors Signal Transducers activators Cytokine NF- B NF-kappaB Signaling Signalling STAT 2798,

extended description :

Selective STAT3 inhibitor

chemical name text :

6-Nitrobenzo[b]thiophene 1,1-dioxide

formula :

C 8 H 5 NO 4 S

formula text :

C8H5NO4S

cas num :

19983-44-9

2020 USD :

2021 USD :

87 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage