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company name :
Tocris Bioscience
product type :
chemical
product name :
Stattic
catalog :
2798/10
quantity :
10 mg (also 50 mg)
price :
113 USD
more info or order :
citations: 24
Reference
Kuzumi A, Yoshizaki A, Matsuda K, Kotani H, Norimatsu Y, Fukayama M, et al. Interleukin-31 promotes fibrosis and T helper 2 polarization in systemic sclerosis. Nat Commun. 2021;12:5947 pubmed publisher
Subramanian K, Neill D, Malak H, Spelmink L, Khandaker S, Dalla Libera Marchiori G, et al. Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival. Nat Microbiol. 2019;4:62-70 pubmed publisher
Fan P, Tyagi A, Agboke F, Mathur R, Pokharel N, Jordan V. Modulation of nuclear factor-kappa B activation by the endoplasmic reticulum stress sensor PERK to mediate estrogen-induced apoptosis in breast cancer cells. Cell Death Discov. 2018;4:15 pubmed publisher
Petes C, Mariani M, Yang Y, Grandvaux N, Gee K. Interleukin (IL)-6 Inhibits IL-27- and IL-30-Mediated Inflammatory Responses in Human Monocytes. Front Immunol. 2018;9:256 pubmed publisher
Dong J, An X, Zhong H, Wang Y, Shang J, Zhou J. Interleukin-22 participates in the inflammatory process of vitiligo. Oncotarget. 2017;8:109161-109174 pubmed publisher
Roy R, Dagher A, Butterfield C, Moses M. ADAM12 Is a Novel Regulator of Tumor Angiogenesis via STAT3 Signaling. Mol Cancer Res. 2017;15:1608-1622 pubmed publisher
Banerjee K, Keasey M, Razskazovskiy V, Visavadiya N, Jia C, Hagg T. Reduced FAK-STAT3 signaling contributes to ER stress-induced mitochondrial dysfunction and death in endothelial cells. Cell Signal. 2017;36:154-162 pubmed publisher
Visavadiya N, Keasey M, Razskazovskiy V, Banerjee K, Jia C, Lovins C, et al. Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3. Cell Commun Signal. 2016;14:32 pubmed
Peda J, Salah S, Wallace D, Fields P, Grantham C, Fields T, et al. Autocrine IL-10 activation of the STAT3 pathway is required for pathological macrophage differentiation in polycystic kidney disease. Dis Model Mech. 2016;9:1051-61 pubmed publisher
Taylor P, Roy S, Meszaros E, Sun Y, Howell S, Malemud C, et al. JAK/STAT regulation of Aspergillus fumigatus corneal infections and IL-6/23-stimulated neutrophil, IL-17, elastase, and MMP9 activity. J Leukoc Biol. 2016;100:213-22 pubmed publisher
Ko H, Park B, Choi S, Kang H, Kim A, Kim H, et al. STAT3 and ERK Signaling Pathways Are Implicated in the Invasion Activity by Oncostatin M through Induction of Matrix Metalloproteinases 2 and 9. Yonsei Med J. 2016;57:761-8 pubmed publisher
Yang H, Yamazaki T, Pietrocola F, Zhou H, Zitvogel L, Ma Y, et al. STAT3 Inhibition Enhances the Therapeutic Efficacy of Immunogenic Chemotherapy by Stimulating Type 1 Interferon Production by Cancer Cells. Cancer Res. 2015;75:3812-22 pubmed publisher
Okada S, Han S, Patel E, Yang L, Chang L. STAT3 signaling contributes to the high effector activities of interleukin-15-derived dendritic cells. Immunol Cell Biol. 2015;93:461-71 pubmed publisher
Conner C, Ackerman K, Lahne M, Hobgood J, Hyde D. Repressing notch signaling and expressing TNFα are sufficient to mimic retinal regeneration by inducing Müller glial proliferation to generate committed progenitor cells. J Neurosci. 2014;34:14403-19 pubmed publisher
Shravah J, Wang B, Pavlovic M, Kumar U, Chen D, Luo H, et al. Propofol mediates signal transducer and activator of transcription 3 activation and crosstalk with phosphoinositide 3-kinase/AKT. JAKSTAT. 2014;3:e29554 pubmed publisher
Natarajan R, Singal V, Benes R, Gao J, Chan H, Chen H, et al. STAT3 modulation to enhance motor neuron differentiation in human neural stem cells. PLoS ONE. 2014;9:e100405 pubmed publisher
Liu X, Tian Y, Lu N, Gin T, Cheng C, Chan M. Stat3 inhibition attenuates mechanical allodynia through transcriptional regulation of chemokine expression in spinal astrocytes. PLoS ONE. 2013;8:e75804 pubmed publisher
Beales I, Garcia Morales C, Ogunwobi O, Mutungi G. Adiponectin inhibits leptin-induced oncogenic signalling in oesophageal cancer cells by activation of PTP1B. Mol Cell Endocrinol. 2014;382:150-158 pubmed publisher
Haynes T, Luz Madrigal A, Reis E, Echeverri Ruiz N, Grajales Esquivel E, Tzekou A, et al. Complement anaphylatoxin C3a is a potent inducer of embryonic chick retina regeneration. Nat Commun. 2013;4:2312 pubmed publisher
Price R, Song J, Bingmer K, Kim T, Yi J, Nowicki M, et al. Cytomegalovirus contributes to glioblastoma in the context of tumor suppressor mutations. Cancer Res. 2013;73:3441-50 pubmed publisher
Keasey M, Kang S, Lovins C, Hagg T. Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression. Cell Commun Signal. 2013;11:35 pubmed publisher
Hodge L, Ziesmer S, Yang Z, Secreto F, Gertz M, Novak A, et al. IL-21 in the bone marrow microenvironment contributes to IgM secretion and proliferation of malignant cells in Waldenstrom macroglobulinemia. Blood. 2012;120:3774-82 pubmed publisher
Katz E, Sims A, Sproul D, Caldwell H, Dixon M, Meehan R, et al. Targeting of Rac GTPases blocks the spread of intact human breast cancer. Oncotarget. 2012;3:608-19 pubmed
Beales I, Ogunwobi O. Glycine-extended gastrin inhibits apoptosis in Barrett's oesophageal and oesophageal adenocarcinoma cells through JAK2/STAT3 activation. J Mol Endocrinol. 2009;42:305-18 pubmed publisher
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
2798
SKU :
2798/10
product name :
Stattic
description :
Selective STAT3 inhibitor
target :
STAT Inhibitors
unit size :
10 mg (also 50 mg)
category :
Small Molecules
purity :
98%
storage :
Store at +4°C
observed molecular weight :
211.19
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Stattic is a small molecule inhibitor of STAT3. Inhibits binding of tyrosine-phosphorylated peptide motifs to STAT3 SH2 domain and inhibits STAT3 activation, dimerization and nuclear translocation. Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. Induces apoptosis in STAT3-dependent cancer cell lines.
product keywords :
Selective STAT3 inhibitors inhibits STAT Transcription Factors Signal Transducers activators Cytokine NF- B NF-kappaB Signaling Signalling STAT 2798,
extended description :
Selective STAT3 inhibitor
chemical name text :
6-Nitrobenzo[b]thiophene 1,1-dioxide
formula :
C8H5NO4S
formula text :
C8H5NO4S
cas num :
19983-44-9
USD :
109
USD 2025 :
113 USD
product details :
Selective STAT3 inhibitor
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK