O-1602 | Tocris Bioscience 2797 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

O-1602

catalog :

2797

quantity :

10 mg

price :

227 USD

more info or order :

Tocris Bioscience product webpage

citations: 10

Reference
Saliba S, Jauch H, Gargouri B, Keil A, Hurrle T, Volz N, et al. Anti-neuroinflammatory effects of GPR55 antagonists in LPS-activated primary microglial cells. J Neuroinflammation. 2018;15:322 pubmed publisher
Schwartz M, Böckmann S, Hinz B. Up-regulation of heme oxygenase-1 expression and inhibition of disease-associated features by cannabidiol in vascular smooth muscle cells. Oncotarget. 2018;9:34595-34616 pubmed publisher
Hill J, Zuluaga Ramirez V, Gajghate S, Winfield M, Persidsky Y. Activation of GPR55 increases neural stem cell proliferation and promotes early adult hippocampal neurogenesis. Br J Pharmacol. 2018;175:3407-3421 pubmed publisher
Shi Q, Yang L, Shi W, Wang L, Zhou S, Guan S, et al. The novel cannabinoid receptor GPR55 mediates anxiolytic-like effects in the medial orbital cortex of mice with acute stress. Mol Brain. 2017;10:38 pubmed publisher
Ailte I, Lingelem A, Kavaliauskiene S, Bergan J, Kvalvaag A, Myrann A, et al. Addition of lysophospholipids with large head groups to cells inhibits Shiga toxin binding. Sci Rep. 2016;6:30336 pubmed publisher
Hanlon K, Lozano Ondoua A, Umaretiya P, Symons Liguori A, Chandramouli A, Moy J, et al. Modulation of breast cancer cell viability by a cannabinoid receptor 2 agonist, JWH-015, is calcium dependent. Breast Cancer (Dove Med Press). 2016;8:59-71 pubmed publisher
Williams J, Appelberg S, Goldberger B, Klein T, Sleasman J, Goodenow M. ?(9)-Tetrahydrocannabinol treatment during human monocyte differentiation reduces macrophage susceptibility to HIV-1 infection. J Neuroimmune Pharmacol. 2014;9:369-79 pubmed publisher
Romero Zerbo S, Rafacho A, Diaz Arteaga A, Suarez J, Quesada I, Imbernon M, et al. A role for the putative cannabinoid receptor GPR55 in the islets of Langerhans. J Endocrinol. 2011;211:177-85 pubmed publisher
Schicho R, Bashashati M, Bawa M, McHugh D, Saur D, Hu H, et al. The atypical cannabinoid O-1602 protects against experimental colitis and inhibits neutrophil recruitment. Inflamm Bowel Dis. 2011;17:1651-64 pubmed publisher
Daly C, Ross R, Whyte J, Henstridge C, Irving A, McGrath J. Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and 'cannabinoid-like' receptors in small arteries. Br J Pharmacol. 2010;159:787-96 pubmed publisher

product information

brand :

Tocris

master code :

2797

SKU :

2797/10

product name :

O-1602

description :

Potent GPR55 agonist

target :

GPR55 Receptor Agonists

category :

Small Molecules

unit size :

10 mg

purity :

97%

observed molecular weight :

258.36

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Analog of cannabidiol that is a potent agonist at the GPR55 cannabinoid receptor (EC50 values are 13, 30000 and 30000 nM for GPR55, CB1 and CB2 receptors respectively). Induces activation of RhoA, cdc42 and rac1. Increases proliferation of neural stem cells NSCs in vitro and in vivo . Also promotes neurogenesis in vivo .

catalog number base :

2797

product keywords :

Potent GPR55 receptor agonists cannabinoids Receptors 0-1602 GPR55 2797,

extended description :

Potent GPR55 agonist

chemical name text :

5-Methyl-4-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-1,3-benzenediol

formula :

C 17 H 22 O 2

formula text :

C17H22O2

cas num :

317321-41-8

2020 USD :

218

2021 USD :

227 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage