Jasplakinolide | Tocris Bioscience 2792/100U product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Jasplakinolide

catalog :

2792/100U

quantity :

100 ug

price :

439 USD

more info or order :

Tocris Bioscience product webpage

citations: 10

Reference
Pfitzer L, Moser C, Gegenfurtner F, Arner A, Foerster F, Atzberger C, et al. Targeting actin inhibits repair of doxorubicin-induced DNA damage: a novel therapeutic approach for combination therapy. Cell Death Dis. 2019;10:302 pubmed publisher
Warchal S, Dawson J, Carragher N. Evaluation of Machine Learning Classifiers to Predict Compound Mechanism of Action When Transferred across Distinct Cell Lines. SLAS Discov. 2019;24:224-233 pubmed publisher
Zhu B, Rippe C, Holmberg J, Zeng S, Perisic L, Albinsson S, et al. Nexilin/NEXN controls actin polymerization in smooth muscle and is regulated by myocardin family coactivators and YAP. Sci Rep. 2018;8:13025 pubmed publisher
Neumann N, Perrone M, Veldhuis J, Huebner R, Zhan H, Devreotes P, et al. Coordination of Receptor Tyrosine Kinase Signaling and Interfacial Tension Dynamics Drives Radial Intercalation and Tube Elongation. Dev Cell. 2018;45:67-82.e6 pubmed publisher
Mordue K, Hawley B, Satchwell T, Toye A. CD47 surface stability is sensitive to actin disruption prior to inclusion within the band 3 macrocomplex. Sci Rep. 2017;7:2246 pubmed publisher
Galvez B, Gross N, Sumikawa K. Activation of Î±7 nicotinic acetylcholine receptors protects potentiated synapses from depotentiation during theta pattern stimulation in the hippocampal CA1 region of rats. Neuropharmacology. 2016;105:378-387 pubmed publisher
LeClaire L, Fortwendel J. Differential Support of Aspergillus fumigatus Morphogenesis by Yeast and Human Actins. PLoS ONE. 2015;10:e0142535 pubmed publisher
Krawczyk K, Yao Mattisson I, Ekman M, Oskolkov N, Grantinge R, Kotowska D, et al. Myocardin Family Members Drive Formation of Caveolae. PLoS ONE. 2015;10:e0133931 pubmed publisher
TurczyÅ„ska K, SwÃ¤rd K, Hien T, Wohlfahrt J, Mattisson I, Ekman M, et al. Regulation of smooth muscle dystrophin and synaptopodin 2 expression by actin polymerization and vascular injury. Arterioscler Thromb Vasc Biol. 2015;35:1489-97 pubmed publisher
Ruprecht V, Wieser S, Callan Jones A, Smutny M, Morita H, Sako K, et al. Cortical contractility triggers a stochastic switch to fast amoeboid cell motility. Cell. 2015;160:673-685 pubmed publisher

product information

brand :

Tocris

master code :

2792

SKU :

2792/100U

product name :

Jasplakinolide

description :

Stabilizes F-actin; promotes actin polymerization

target :

Actin-related Products

category :

Small Molecules

unit sizes :

100 ug

purity :

97%

observed molecular weight :

709.67

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Jasplakinolide rapidly stabilizes pre-formed actin filaments and inhibits their disassembly in vitro . Also induces polymerization of actin monomers into F-actin in vivo . Shown to bind to F-actin competitively with phalloidin (Cat. No. 4535) (Kd ~ 15 nM). Exhibits antifungal and antiproliferative effects (IC50 = 35 nM for antiproliferative activity in PC3 cells). Cell permeable.

extended description :

Stabilizes F-actin; promotes actin polymerization

chemical name text :

Cyclo[(3R)-3-(4-hydroxyphenyl)- -alanyl-(2S,4E,6R,8S)-8-hydroxy-2,4,6-trimethyl-4-nonenoyl-L-alanyl-2-bromo-N-methyl-D-tryptophyl]

formula :

C 36 H 45 BrN 4 O 6

formula text :

C36H45BrN4O6

cas num :

102396-24-7

USD :

439 USD

product details :

Stabilizes F-actin; promotes actin polymerization

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage