product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
EX 527
catalog :
2780/1
quantity :
1 mg (also 10 mg, 50 mg)
price :
131 USD
more info or order :
citations: 26
Reference
Sun Y, Wang Y, Sun X, Cheng S, Li L, Zhao Y, et al. The role of autophagy during murine primordial follicle assembly. Aging (Albany NY). 2018;10:197-211 pubmed publisher
Deng Z, Jin J, Wang Z, Wang Y, Gao Q, Zhao J. The metal nanoparticle-induced inflammatory response is regulated by SIRT1 through NF-?B deacetylation in aseptic loosening. Int J Nanomedicine. 2017;12:3617-3636 pubmed publisher
Sellner S, Paricio Montesinos R, Spieß A, Masuch A, Erny D, Harsan L, et al. Microglial CX3CR1 promotes adult neurogenesis by inhibiting Sirt 1/p65 signaling independent of CX3CL1. Acta Neuropathol Commun. 2016;4:102 pubmed publisher
Weinberg R, Mufson E, Counts S. Evidence for a neuroprotective microRNA pathway in amnestic mild cognitive impairment. Front Neurosci. 2015;9:430 pubmed publisher
Joo H, Yun M, Jeong J, Park E, Shin H, Woo S, et al. SIRT1 deacetylates and stabilizes hypoxia-inducible factor-1α (HIF-1α) via direct interactions during hypoxia. Biochem Biophys Res Commun. 2015;462:294-300 pubmed publisher
Lim H, Kang S, Ryu J, Schilling B, Fei M, Lee I, et al. SIRT1 deacetylates RORγt and enhances Th17 cell generation. J Exp Med. 2015;212:607-17 pubmed publisher
Beier U, Angelin A, Akimova T, Wang L, Liu Y, Xiao H, et al. Essential role of mitochondrial energy metabolism in Foxp3⁺ T-regulatory cell function and allograft survival. FASEB J. 2015;29:2315-26 pubmed publisher
Zhang S, Zhu L, Chen H, Zhang R, Zhang P, Jiang D, et al. Interferon regulatory factor 9 is critical for neointima formation following vascular injury. Nat Commun. 2014;5:5160 pubmed publisher
Fan Y, Meley D, Pizer B, Sée V. Mir-34a mimics are potential therapeutic agents for p53-mutated and chemo-resistant brain tumour cells. PLoS ONE. 2014;9:e108514 pubmed publisher
Chen H, Guo S, Li Z, Lu Y, Jiang D, Zhang R, et al. A critical role for interferon regulatory factor 9 in cerebral ischemic stroke. J Neurosci. 2014;34:11897-912 pubmed publisher
Li Y, Wang K, Feng Y, Fan C, Wang F, Yan J, et al. Novel role of silent information regulator 1 in acute endothelial cell oxidative stress injury. Biochim Biophys Acta. 2014;1842:2246-56 pubmed publisher
Caruso R, Marafini I, Franzè E, Stolfi C, Zorzi F, Monteleone I, et al. Defective expression of SIRT1 contributes to sustain inflammatory pathways in the gut. Mucosal Immunol. 2014;7:1467-79 pubmed publisher
Akimova T, Xiao H, Liu Y, Bhatti T, Jiao J, Eruslanov E, et al. Targeting sirtuin-1 alleviates experimental autoimmune colitis by induction of Foxp3+ T-regulatory cells. Mucosal Immunol. 2014;7:1209-20 pubmed publisher
Jiang Y, Zsombok A. Regulation of neurons in the dorsal motor nucleus of the vagus by SIRT1. Front Neurosci. 2014;7:270 pubmed publisher
Gu C, Xing Y, Jiang L, Chen M, Xu M, Yin Y, et al. Impaired cardiac SIRT1 activity by carbonyl stress contributes to aging-related ischemic intolerance. PLoS ONE. 2013;8:e74050 pubmed publisher
Armour S, Bennett E, Braun C, Zhang X, McMahon S, Gygi S, et al. A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. Mol Cell Biol. 2013;33:1487-502 pubmed publisher
Yan W, Fang Z, Yang Q, Dong H, Lu Y, Lei C, et al. SirT1 mediates hyperbaric oxygen preconditioning-induced ischemic tolerance in rat brain. J Cereb Blood Flow Metab. 2013;33:396-406 pubmed publisher
Pietrocola F, Mariño G, Lissa D, Vacchelli E, Malik S, Niso Santano M, et al. Pro-autophagic polyphenols reduce the acetylation of cytoplasmic proteins. Cell Cycle. 2012;11:3851-60 pubmed publisher
Paffett M, Lucas S, Campen M. Resveratrol reverses monocrotaline-induced pulmonary vascular and cardiac dysfunction: a potential role for atrogin-1 in smooth muscle. Vascul Pharmacol. 2012;56:64-73 pubmed publisher
Peng L, Yuan Z, Ling H, Fukasawa K, ROBERTSON K, Olashaw N, et al. SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities. Mol Cell Biol. 2011;31:4720-34 pubmed publisher
Cottam E, Maier H, Manifava M, Vaux L, Chandra Schoenfelder P, Gerner W, et al. Coronavirus nsp6 proteins generate autophagosomes from the endoplasmic reticulum via an omegasome intermediate. Autophagy. 2011;7:1335-47 pubmed publisher
Kumar R, Hunt C, Gupta A, Nannepaga S, Pandita R, Shay J, et al. Purkinje cell-specific males absent on the first (mMof) gene deletion results in an ataxia-telangiectasia-like neurological phenotype and backward walking in mice. Proc Natl Acad Sci U S A. 2011;108:3636-41 pubmed publisher
Liu T, Yoza B, El Gazzar M, Vachharajani V, McCall C. NAD+-dependent SIRT1 deacetylase participates in epigenetic reprogramming during endotoxin tolerance. J Biol Chem. 2011;286:9856-64 pubmed publisher
Dietrich M, Antunes C, Geliang G, Liu Z, Borok E, Nie Y, et al. Agrp neurons mediate Sirt1's action on the melanocortin system and energy balance: roles for Sirt1 in neuronal firing and synaptic plasticity. J Neurosci. 2010;30:11815-25 pubmed publisher
Xie Y, Park J, Kim D, Hwang J, Oh S, Park S, et al. Transcriptional corepressor SMILE recruits SIRT1 to inhibit nuclear receptor estrogen receptor-related receptor gamma transactivation. J Biol Chem. 2009;284:28762-74 pubmed publisher
Nie Y, Erion D, Yuan Z, Dietrich M, Shulman G, Horvath T, et al. STAT3 inhibition of gluconeogenesis is downregulated by SirT1. Nat Cell Biol. 2009;11:492-500 pubmed publisher
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
2780
SKU :
2780/1
product name :
EX 527
description :
Selective SIRT1 inhibitor
target :
Class III Histone Deacetylases Inhibitors
unit size :
1 mg (also 10 mg, 50 mg)
category :
Small Molecules
purity :
98%
storage :
Store at +4°C
observed molecular weight :
248.71
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
EX 527 is a selective inhibitor of SIRT1 that does not inhibit histone deacetylase (HDAC) or other sirtuin deacetylase family members (IC50 values are 98, 19600, 48700, 100000 and 100000 nM for SIRT1, SIRT2, SIRT3, HDAC and NADase respectively). In an animal model of Huntington s disease, EX 527 rescues neuronal degeneration, extends lifespan, reduces huntingtin inclusions and prevents ventricular enlargement. EX 527 enhances p53 acetylation in response to DNA damaging agents. Orally bioavailable and brain penetrant.
product keywords :
Selective SIRT1 inhibitors inhibits Sirtuin Sir2-like Family Deacetylases EX527 Selisistat huntingtons huntingtin neurodegeneration Class III HDACs (Sirtuins) 2780,
extended description :
Selective SIRT1 inhibitor
chemical name text :
6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
formula :
C13H13ClN2O
formula text :
C13H13ClN2O
cas num :
49843-98-3
USD :
129
USD 2025 :
131 USD
product details :
Selective SIRT1 inhibitor
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK