CP 154526 | Tocris Bioscience 2779 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

CP 154526

catalog :

2779

quantity :

10 mg (also 50 mg)

price :

216 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Klampfl S, Brunton P, Bayerl D, Bosch O. CRF-R1 activation in the anterior-dorsal BNST induces maternal neglect in lactating rats via an HPA axis-independent central mechanism. Psychoneuroendocrinology. 2016;64:89-98 pubmed publisher

product information

brand :

Tocris

master code :

2779

SKU :

2779/10

product name :

CP 154526

description :

Selective, non-peptide CRF1 antagonist

target :

CRF1 Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

400.99

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective, non-peptide CRF1 receptor antagonist (Ki values are 2.7 and 10000 nM for CRF1 and CRF2 receptors respectively). Blocks CRF-induced adenylate cyclase activation (Ki = 3.7 nM) and attenuates activation of the HPA axis by CRF. Displays anxiolytic-like activity in the rat elevated plus-maze test; brain penetrant.

catalog number base :

2779

product keywords :

Selective non-peptide CRF1 antagonists Corticotropin-Releasing Factor1 Receptors CP154526 Pfizer CRF1 Receptors 2779,

extended description :

Selective, non-peptide CRF1 antagonist

chemical name text :

N-Butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride

formula :

C 23 H 32 N 4 .HCl

formula text :

C23H32N4.HCl

cas num :

257639-98-8

2020 USD :

207

2021 USD :

216 USD

storage :

Desiccate at +4°C

more info or order :

Tocris Bioscience product webpage