Antalarmin hydrochloride | Tocris Bioscience 2778 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Antalarmin hydrochloride

catalog :

2778

quantity :

10 mg (also 50 mg)

price :

216 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Narla C, Dunn H, Ferguson S, Poulter M. Suppression of piriform cortex activity in rat by corticotropin-releasing factor 1 and serotonin 2A/C receptors. Front Cell Neurosci. 2015;9:200 pubmed publisher
Zhao Shea R, DeGroot S, Liu L, Vallaster M, Pang X, Su Q, et al. Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal. Nat Commun. 2015;6:6770 pubmed publisher
Gray J, Vecchiarelli H, Morena M, Lee T, Hermanson D, Kim A, et al. Corticotropin-releasing hormone drives anandamide hydrolysis in the amygdala to promote anxiety. J Neurosci. 2015;35:3879-92 pubmed publisher
Wood S, Verhoeven R, Savit A, Rice K, Fischbach P, Woods J. Facilitation of cardiac vagal activity by CRF-R1 antagonists during swim stress in rats. Neuropsychopharmacology. 2006;31:2580-90 pubmed

product information

brand :

Tocris

master code :

2778

SKU :

2778/10

product name :

Antalarmin hydrochloride

description :

CRF1 antagonist

target :

CRF1 Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

415.01

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Non-peptide corticotropin-releasing hormone receptor 1 (CRF1) antagonist (Ki = 1 nM). Suppresses CRF-induced ACTH secretion. Blocks CRF- and novelty-induced anxiety-like behavior in animal models of anxiety.

catalog number base :

2778

product keywords :

CRF1 antagonists Corticotropin-Releasing Factor1 Receptors CRF1 Receptors 2778,

extended description :

CRF1 antagonist

chemical name text :

N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride

formula :

C 24 H 34 N 4 .HCl

formula text :

C24H34N4.HCl

cas num :

220953-69-5

2020 USD :

207

2021 USD :

216 USD

storage :

Desiccate at +4°C

more info or order :

Tocris Bioscience product webpage