Sumanirole maleate | Tocris Bioscience 2773/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Sumanirole maleate

catalog :

2773/10

quantity :

10 mg (also 50 mg)

price :

214 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Saika F, Matsuzaki S, Kobayashi D, Kiguchi N, Kishioka S. Chemokine CXCL1 is responsible for cocaine-induced reward in mice. Neuropsychopharmacol Rep. 2018;38:145-148 pubmed publisher
Chai H, Diaz Castro B, Shigetomi E, Monte E, Octeau J, Yu X, et al. Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence. Neuron. 2017;95:531-549.e9 pubmed publisher

product information

brand :

Tocris

master code :

2773

SKU :

2773/10

product name :

Sumanirole maleate

description :

Selective D2 agonist

target :

Dopamine D2 Receptor Agonists

category :

Small Molecules

unit sizes :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

319.31

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Sumanirole maleate is a high affinity D2 receptor agonist (EC50 values are between 17 and 75 nM in cell-based assays). Originally reported to exhibit 200-fold selectivity for the D2 receptor versus other dopamine receptor subtypes (Ki values are 9.0, 1940, 2190 and 7140 for D2, D3, D4 and D1 receptors respectively). More recently reported to be around 32-fold selective for D2 over D3 receptors (Ki values are 17.1 and 546 nM respectively). Exhibits antiParkinsonian activity.

extended description :

Selective D2 agonist

chemical name text :

(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (2Z)-2-butenedioate

formula :

C 11 H 13 N 3 O.C 4 H 4 O 4

formula text :

C11H13N3O.C4H4O4

cas num :

179386-44-8

USD :

214 USD

product details :

Selective D2 agonist

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage