Philanthotoxin 74 | Tocris Bioscience 2770 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Philanthotoxin 74

catalog :

2770

quantity :

1 mg (also 10 mg, 50 mg)

price :

101 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Zhao J, Li A, Rajsombath M, Dang Y, Selkoe D, Li S. Soluble A? Oligomers Impair Dipolar Heterodendritic Plasticity by Activation of mGluR in the Hippocampal CA1 Region. iScience. 2018;6:138-150 pubmed publisher
Kim S, Ziff E. Calcineurin mediates synaptic scaling via synaptic trafficking of Ca2+-permeable AMPA receptors. PLoS Biol. 2014;12:e1001900 pubmed publisher

product information

brand :

Tocris

master code :

2770

SKU :

2770/1

product name :

Philanthotoxin 74

description :

GluA1 and GluA3 selective AMPA antagonist

target :

AMPA Receptor Antagonists

category :

Small Molecules

unit size :

1 mg (also 10 mg, 50 mg)

purity :

98%

observed molecular weight :

507.54

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AMPA receptor antagonist. Non-selective homomeric GluA3 and GluA1 receptor antagonist (IC50 values are 263 and 296 nM respectively). Inhibits homomeric GluA3 and GluA1 with a 100-fold greater potency than heteromeric GluA1/2 and GluA2/3 receptors.

catalog number base :

2770

product keywords :

GluR1/2 selective AMPA antagonists Glutamate Receptors iGluR Ionotropic Philanthotoxin74 PhTx74 homomeric GluR3 GluR1 GluR2/3 GluA1 GluA2 GluA3 PhTx-74 AMPA Receptors 2770,

extended description :

GluA1 and GluA3 selective AMPA antagonist

chemical name text :

(S)-N-[7-[(4-Aminobutyl)amino]heptyl]-4-hydroxy- -[(1-oxobutyl)amino]benzenepropanamide dihydrochloride

formula :

C 24 H 42 N 4 O 3 .2HCl

formula text :

C24H42N4O3.2HCl

cas num :

1227301-51-0

2020 USD :

2021 USD :

101 USD

alt names :

PhTx-74

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage