product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
PQ 401
catalog :
2768/10
quantity :
10 mg (also 50 mg)
price :
216 USD
more info or order :
citations: 6
Reference
Kim W, Zou G, Pan W, Fricke N, Faizi H, Kim S, et al. The Neutrally Charged Diarylurea Compound PQ401 Kills Antibiotic-Resistant and Antibiotic-Tolerant Staphylococcus aureus. MBio. 2020;11: pubmed publisher
Ilatovskaya D, Palygin O, Levchenko V, Staruschenko A. Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli. Am J Physiol Cell Physiol. 2013;305:C1050-9 pubmed publisher
Shen X, Xi G, Maile L, Wai C, Rosen C, Clemmons D. Insulin-like growth factor (IGF) binding protein 2 functions coordinately with receptor protein tyrosine phosphatase ? and the IGF-I receptor to regulate IGF-I-stimulated signaling. Mol Cell Biol. 2012;32:4116-30 pubmed
Jameson M, Beckler A, Taniguchi L, Allak A, Vanwagner L, Lee N, et al. Activation of the insulin-like growth factor-1 receptor induces resistance to epidermal growth factor receptor antagonism in head and neck squamous carcinoma cells. Mol Cancer Ther. 2011;10:2124-34 pubmed publisher
Sanchez Alavez M, Osborn O, Tabarean I, Holmberg K, Eberwine J, Kahn C, et al. Insulin-like growth factor 1-mediated hyperthermia involves anterior hypothalamic insulin receptors. J Biol Chem. 2011;286:14983-90 pubmed publisher
Radhakrishnan Y, Busby W, Shen X, Maile L, Clemmons D. Insulin-like growth factor-I-stimulated insulin receptor substrate-1 negatively regulates Src homology 2 domain-containing protein-tyrosine phosphatase substrate-1 function in vascular smooth muscle cells. J Biol Chem. 2010;285:15682-95 pubmed publisher
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
2768
SKU :
2768/10
product name :
PQ 401
description :
IGF1R inhibitor
target :
Insulin and Insulin-like Receptor Inhibitors
unit size :
10 mg (also 50 mg)
category :
Small Molecules
purity :
99%
storage :
Store at +4°C
observed molecular weight :
341.79
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
PQ 401 is an insulin-like growth factor receptor (IGF1R) inhibitor. Suppresses IGF-stimulated IGF-IR autophosphorylation with an IC50 value of 12 u M. Inhibits growth of MCF-7 breast cancer cells in vitro and in vivo .
product keywords :
IGF-IR inhibitors inhibits Receptors Insulin-like Receptor Tyrosine Kinases RTKs PQ401 Insulin and insulin-like Receptors Insulin and Insulin-like Receptors 2768,
extended description :
IGF1R inhibitor
chemical name text :
N-(5-Chloro-2-methoxyphenyl)-N -(2-methyl-4-quinolinyl)urea
formula :
C18H16ClN3O2
formula text :
C18H16ClN3O2
cas num :
196868-63-0
USD :
213
USD 2025 :
216 USD
product details :
IGF1R inhibitor
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK