product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
Naspm trihydrochloride
catalog :
2766/10
quantity :
10 mg
price :
257 USD
more info or order :
citations: 13
Reference
Zhang R, DU W, Prober D, Du J. Müller Glial Cells Participate in Retinal Waves via Glutamate Transporters and AMPA Receptors. Cell Rep. 2019;27:2871-2880.e2 pubmed publisher
Purkey A, Woolfrey K, Crosby K, Stich D, Chick W, Aoto J, et al. AKAP150 Palmitoylation Regulates Synaptic Incorporation of Ca2+-Permeable AMPA Receptors to Control LTP. Cell Rep. 2018;25:974-987.e4 pubmed publisher
Park P, Sanderson T, Amici M, Choi S, Bortolotto Z, Zhuo M, et al. Calcium-Permeable AMPA Receptors Mediate the Induction of the Protein Kinase A-Dependent Component of Long-Term Potentiation in the Hippocampus. J Neurosci. 2016;36:622-31 pubmed publisher
Megill A, Tran T, Eldred K, Lee N, Wong P, HOE H, et al. Defective Age-Dependent Metaplasticity in a Mouse Model of Alzheimer's Disease. J Neurosci. 2015;35:11346-57 pubmed publisher
Blanco Suárez E, Fiuza M, Liu X, Chakkarapani E, Hanley J. Differential Tiam1/Rac1 activation in hippocampal and cortical neurons mediates differential spine shrinkage in response to oxygen/glucose deprivation. J Cereb Blood Flow Metab. 2014;34:1898-906 pubmed publisher
Roy A, Modi K, Khasnavis S, Ghosh S, Watson R, Pahan K. Enhancement of morphological plasticity in hippocampal neurons by a physically modified saline via phosphatidylinositol-3 kinase. PLoS ONE. 2014;9:e101883 pubmed publisher
Kim S, Ziff E. Calcineurin mediates synaptic scaling via synaptic trafficking of Ca2+-permeable AMPA receptors. PLoS Biol. 2014;12:e1001900 pubmed publisher
Fernandes J, Vieira M, Carreto L, Santos M, Duarte C, Carvalho A, et al. In vitro ischemia triggers a transcriptional response to down-regulate synaptic proteins in hippocampal neurons. PLoS ONE. 2014;9:e99958 pubmed publisher
Lee H, Brott B, Kirkby L, Adelson J, Cheng S, Feller M, et al. Synapse elimination and learning rules co-regulated by MHC class I H2-Db. Nature. 2014;509:195-200 pubmed publisher
Liu M, Kang S, Shi T, Koga K, Zhang M, Collingridge G, et al. Long-term potentiation of synaptic transmission in the adult mouse insular cortex: multielectrode array recordings. J Neurophysiol. 2013;110:505-21 pubmed publisher
Caba ero D, Baker A, Zhou S, Hargett G, Irie T, Xia Y, et al. Pain after discontinuation of morphine treatment is associated with synaptic increase of GluA4-containing AMPAR in the dorsal horn of the spinal cord. Neuropsychopharmacology. 2013;38:1472-84 pubmed publisher
Jaafari N, Henley J, Hanley J. PICK1 mediates transient synaptic expression of GluA2-lacking AMPA receptors during glycine-induced AMPA receptor trafficking. J Neurosci. 2012;32:11618-30 pubmed publisher
Villers A, Godaux E, Ris L. Long-lasting LTP requires neither repeated trains for its induction nor protein synthesis for its development. PLoS ONE. 2012;7:e40823 pubmed publisher
product information
brand :
Tocris
master code :
2766
SKU :
2766/10
product name :
Naspm trihydrochloride
description :
Ca2+-permeable AMPA antagonist
target :
AMPA Receptor Antagonists
category :
Small Molecules
unit sizes :
10 mg
purity :
97%
observed molecular weight :
479.91
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Naspm trihydrochloride is a selective antagonist of Ca2+-permeable AMPA receptors; blocks AMPA receptors lacking the GluA2 subunit. Protects hippocampal neurons against global ischemia-induced cell death.
extended description :
Ca2+-permeable AMPA antagonist
chemical name text :
N-[3-[[4-[(3-Aminopropyl)amino]butyl]amino]propyl]-1-naphthaleneacetamide trihydrochloride
formula :
C 22 H 34 N 4 O.3HCl
formula text :
C22H34N4O.3HCl
cas num :
1049731-36-3
USD :
257 USD
product details :
Ca2+-permeable AMPA antagonist
alt names :
1-Naphthyl acetyl spermine trihydrochloride
storage :
Desiccate at +4°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK