product summary
Loading...
company name :
Tocris Bioscience
product type :
chemical
product name :
MRS 1754
catalog :
2752
quantity :
10 mg (also 50 mg)
price :
227 USD
more info or order :
citations: 16
Reference
Liu G, Zhang W, Guo J, Kong F, Zhou S, Chen S, et al. Adenosine binds predominantly to adenosine receptor A1 subtype in astrocytes and mediates an immunosuppressive effect. Brain Res. 2018;1700:47-55 pubmed publisher
Wakisaka N, Miyasaka N, Koide T, Masuda M, Hiraki Kajiyama T, Yoshihara Y. An Adenosine Receptor for Olfaction in Fish. Curr Biol. 2017;27:1437-1447.e4 pubmed publisher
Asano T, Tanaka K, Tada A, Shimamura H, Tanaka R, Maruoka H, et al. Aminophylline suppresses stress-induced visceral hypersensitivity and defecation in irritable bowel syndrome. Sci Rep. 2017;7:40214 pubmed publisher
Ledderose C, Hefti M, Chen Y, Bao Y, Seier T, Li L, et al. Adenosine arrests breast cancer cell motility by A3 receptor stimulation. Purinergic Signal. 2016;12:673-685 pubmed
Lemos C, Pinheiro B, Beleza R, Marques J, Rodrigues R, Cunha R, et al. Adenosine A2B receptor activation stimulates glucose uptake in the mouse forebrain. Purinergic Signal. 2015;11:561-9 pubmed publisher
Kohno K, Ohashi E, Sano O, Kusano H, Kunikata T, Arai N, et al. Anti-inflammatory effects of adenosine N1-oxide. J Inflamm (Lond). 2015;12:2 pubmed publisher
Welihinda A, Amento E. Positive allosteric modulation of the adenosine A2a receptor attenuates inflammation. J Inflamm (Lond). 2014;11:37 pubmed publisher
He W, Mazumder A, Wilder T, Cronstein B. Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma. FASEB J. 2013;27:3446-54 pubmed publisher
Garção P, Szabó E, Wopereis S, Castro A, Tome A, Prediger R, et al. Functional interaction between pre-synaptic ?6?2-containing nicotinic and adenosine A2A receptors in the control of dopamine release in the rat striatum. Br J Pharmacol. 2013;169:1600-11 pubmed publisher
Kan Y, Okabayashi T, Yokota S, Yamamoto S, Fujii N, Yamashita T. Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway. J Virol. 2012;86:10338-46 pubmed publisher
Hua X, Chason K, Patel J, Naselsky W, Tilley S. IL-4 amplifies the pro-inflammatory effect of adenosine in human mast cells by changing expression levels of adenosine receptors. PLoS ONE. 2011;6:e24947 pubmed publisher
Pedroza M, Schneider D, Karmouty Quintana H, Coote J, Shaw S, Corrigan R, et al. Interleukin-6 contributes to inflammation and remodeling in a model of adenosine mediated lung injury. PLoS ONE. 2011;6:e22667 pubmed publisher
Zhan E, McIntosh V, Lasley R. Adenosine A?A and A?B receptors are both required for adenosine A? receptor-mediated cardioprotection. Am J Physiol Heart Circ Physiol. 2011;301:H1183-9 pubmed publisher
Gebremedhin D, Weinberger B, Lourim D, Harder D. Adenosine can mediate its actions through generation of reactive oxygen species. J Cereb Blood Flow Metab. 2010;30:1777-90 pubmed publisher
Yu E, Traylor Z, Davis I. Effect of ventilation pressure on alveolar fluid clearance and beta-agonist responses in mice. Am J Physiol Lung Cell Mol Physiol. 2009;297:L785-93 pubmed publisher
Wolk K, Lazarowski E, Traylor Z, Yu E, Jewell N, Durbin R, et al. Influenza A virus inhibits alveolar fluid clearance in BALB/c mice. Am J Respir Crit Care Med. 2008;178:969-76 pubmed publisher
product information
brand :
Tocris
master code :
2752
SKU :
2752/10
product name :
MRS 1754
description :
Selective A2B antagonist
target :
Adenosine A2b Receptor Antagonists
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
98%
observed molecular weight :
486.52
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Selective adenosine A2B receptor antagonist (Ki values are 1.97, 16.8, 403, 503, 570 and 612 nM for hA2B, rA1, hA1, hA2A, hA3 and rA2A receptors respectively).
catalog number base :
2752
product keywords :
Selective A2B antagonists Receptors adenosines MRS1754 Adenosine A2B Receptors 2752,
extended description :
Selective A2B antagonist
chemical name text :
N-(4-Cyanophenyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]-acetamide
formula :
C 26 H 26 N 6 O 4
formula text :
C26H26N6O4
cas num :
264622-58-4
2020 USD :
218
2021 USD :
227 USD
storage :
Desiccate at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK