product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
MRS 1754
catalog :
2752/10
quantity :
10 mg
price :
285 USD
more info or order :
citations: 18
Reference
Liu G, Zhang W, Guo J, Kong F, Zhou S, Chen S, et al. Adenosine binds predominantly to adenosine receptor A1 subtype in astrocytes and mediates an immunosuppressive effect. Brain Res. 2018;1700:47-55 pubmed publisher
Liang D, Woo J, Shao H, Born W, O Brien R, Kaplan H, et al. Ability of γδ T cells to modulate the Foxp3 T cell response is dependent on adenosine. PLoS ONE. 2018;13:e0197189 pubmed publisher
Wakisaka N, Miyasaka N, Koide T, Masuda M, Hiraki Kajiyama T, Yoshihara Y. An Adenosine Receptor for Olfaction in Fish. Curr Biol. 2017;27:1437-1447.e4 pubmed publisher
Asano T, Tanaka K, Tada A, Shimamura H, Tanaka R, Maruoka H, et al. Aminophylline suppresses stress-induced visceral hypersensitivity and defecation in irritable bowel syndrome. Sci Rep. 2017;7:40214 pubmed publisher
Ledderose C, Hefti M, Chen Y, Bao Y, Seier T, Li L, et al. Adenosine arrests breast cancer cell motility by A3 receptor stimulation. Purinergic Signal. 2016;12:673-685 pubmed
Lemos C, Pinheiro B, Beleza R, Marques J, Rodrigues R, Cunha R, et al. Adenosine A2B receptor activation stimulates glucose uptake in the mouse forebrain. Purinergic Signal. 2015;11:561-9 pubmed publisher
Cohen H, Ward A, Hamidzadeh K, Ravid K, Mosser D. IFN-γ Prevents Adenosine Receptor (A2bR) Upregulation To Sustain the Macrophage Activation Response. J Immunol. 2015;195:3828-37 pubmed publisher
Kohno K, Ohashi E, Sano O, Kusano H, Kunikata T, Arai N, et al. Anti-inflammatory effects of adenosine N1-oxide. J Inflamm (Lond). 2015;12:2 pubmed publisher
Welihinda A, Amento E. Positive allosteric modulation of the adenosine A2a receptor attenuates inflammation. J Inflamm (Lond). 2014;11:37 pubmed publisher
He W, Mazumder A, Wilder T, Cronstein B. Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma. FASEB J. 2013;27:3446-54 pubmed publisher
Garção P, Szabó E, Wopereis S, Castro A, Tome A, Prediger R, et al. Functional interaction between pre-synaptic ?6?2-containing nicotinic and adenosine A2A receptors in the control of dopamine release in the rat striatum. Br J Pharmacol. 2013;169:1600-11 pubmed publisher
Kan Y, Okabayashi T, Yokota S, Yamamoto S, Fujii N, Yamashita T. Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway. J Virol. 2012;86:10338-46 pubmed publisher
Hua X, Chason K, Patel J, Naselsky W, Tilley S. IL-4 amplifies the pro-inflammatory effect of adenosine in human mast cells by changing expression levels of adenosine receptors. PLoS ONE. 2011;6:e24947 pubmed publisher
Pedroza M, Schneider D, Karmouty Quintana H, Coote J, Shaw S, Corrigan R, et al. Interleukin-6 contributes to inflammation and remodeling in a model of adenosine mediated lung injury. PLoS ONE. 2011;6:e22667 pubmed publisher
Zhan E, McIntosh V, Lasley R. Adenosine A?A and A?B receptors are both required for adenosine A? receptor-mediated cardioprotection. Am J Physiol Heart Circ Physiol. 2011;301:H1183-9 pubmed publisher
Gebremedhin D, Weinberger B, Lourim D, Harder D. Adenosine can mediate its actions through generation of reactive oxygen species. J Cereb Blood Flow Metab. 2010;30:1777-90 pubmed publisher
Yu E, Traylor Z, Davis I. Effect of ventilation pressure on alveolar fluid clearance and beta-agonist responses in mice. Am J Physiol Lung Cell Mol Physiol. 2009;297:L785-93 pubmed publisher
Wolk K, Lazarowski E, Traylor Z, Yu E, Jewell N, Durbin R, et al. Influenza A virus inhibits alveolar fluid clearance in BALB/c mice. Am J Respir Crit Care Med. 2008;178:969-76 pubmed publisher
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
2752
SKU :
2752/10
product name :
MRS 1754
description :
Selective A2B antagonist
target :
Adenosine A2b Receptor Antagonists
unit size :
10 mg
category :
Small Molecules
purity :
98%
storage :
Desiccate at RT
observed molecular weight :
486.52
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
MRS 1754 is a selective adenosine A2B receptor antagonist (Ki values are 1.97, 16.8, 403, 503, 570 and 612 nM for hA2B, rA1, hA1, hA2A, hA3 and rA2A receptors respectively).
product keywords :
Selective A2B antagonists Receptors adenosines MRS1754 Adenosine A2B Receptors 2752,
extended description :
Selective A2B antagonist
chemical name text :
N-(4-Cyanophenyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]-acetamide
formula :
C26H26N6O4
formula text :
C26H26N6O4
cas num :
264622-58-4
USD :
282
USD 2025 :
285 USD
product details :
Selective A2B antagonist
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK