Dexmedetomidine hydrochloride | Tocris Bioscience 2749/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Dexmedetomidine hydrochloride

catalog :

2749/10

quantity :

10 mg (also 50 mg)

price :

248 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Ma Y, Miracca G, Yu X, Harding E, Miao A, Yustos R, et al. Galanin Neurons Unite Sleep Homeostasis and α2-Adrenergic Sedation. Curr Biol. 2019;29:3315-3322.e3 pubmed publisher
Uchida S, Kobayashi K, Ohno S, Sakagami H, Kohase H, Nagasaka H. Induction of Non-Apoptotic Cell Death by Adrenergic Agonists in Human Oral Squamous Cell Carcinoma Cell Lines. Anticancer Res. 2019;39:3519-3529 pubmed publisher
Rennekamp A, Huang X, Wang Y, Patel S, Lorello P, Cade L, et al. ?1 receptor ligands control a switch between passive and active threat responses. Nat Chem Biol. 2016;12:552-8 pubmed publisher
McAlvin J, Zhan C, Dohlman J, Kolovou P, Salvador Culla B, Kohane D. Corneal Anesthesia With Site 1 Sodium Channel Blockers and Dexmedetomidine. Invest Ophthalmol Vis Sci. 2015;56:3820-6 pubmed publisher
Boucrot E, Ferreira A, Almeida Souza L, Debard S, Vallis Y, Howard G, et al. Endophilin marks and controls a clathrin-independent endocytic pathway. Nature. 2015;517:460-5 pubmed publisher
Garrity A, Botta S, Lazar S, Swor E, Vanini G, Baghdoyan H, et al. Dexmedetomidine-induced sedation does not mimic the neurobehavioral phenotypes of sleep in Sprague Dawley rat. Sleep. 2015;38:73-84 pubmed publisher
Gozzi A, Lepore S, Vicentini E, Merlo Pich E, Bifone A. Differential effect of orexin-1 and CRF-1 antagonism on stress circuits: a fMRI study in the rat with the pharmacological stressor Yohimbine. Neuropsychopharmacology. 2013;38:2120-30 pubmed publisher
Yuki K, Soriano S, Shimaoka M. Sedative drug modulates T-cell and lymphocyte function-associated antigen-1 function. Anesth Analg. 2011;112:830-8 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2749

SKU :

2749/10

product name :

Dexmedetomidine hydrochloride

description :

Potent, highly selective 2 agonist. Active isomer of medetomidine (Cat. No. 5160)

target :

Adrenergic alpha-2 Receptor Agonists

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Desiccate at RT

observed molecular weight :

236.74

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Dexmedetomidine hydrochloride is an active isomer of medetomidine, a potent, highly selective 2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for 2- and 1-adrenoceptors respectively). Displays greater selectivity over 1-adrenoceptors than Clonidine (Cat. No. 0690) and UK 14,304 (1620-, 220- and 300-fold respectively). Active in vivo ; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects. . Racemate also available.

product keywords :

Active isomer 2-Adrenergic alpha2-Adrenergic Receptors 2-adrenoceptor alpha2-adrenoceptors a2-adrenoceptors a2-adrenergic d-Medetomidine hydrochloride Adrenergic Alpha-2 Receptors 2749,

extended description :

Potent, highly selective 2 agonist. Active isomer of medetomidine (Cat. No. 5160)

chemical name text :

4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride

formula :

C13H16N2.HCl

formula text :

C13H16N2.HCl

cas num :

145108-58-3

USD :

240

USD 2025 :

248 USD

product details :

Potent, highly selective 2 agonist. Active isomer of medetomidine (Cat. No. 5160)

alt names :

d -Medetomidine hydrochloride

more info or order :

Tocris Bioscience product webpage