TC 2559 difumarate | Tocris Bioscience 2737/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TC 2559 difumarate

catalog :

2737/10

quantity :

10 mg (also 50 mg)

price :

272 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Kiguchi N, Kobayashi D, Saika F, Matsuzaki S, Kishioka S. Inhibition of peripheral macrophages by nicotinic acetylcholine receptor agonists suppresses spinal microglial activation and neuropathic pain in mice with peripheral nerve injury. J Neuroinflammation. 2018;15:96 pubmed publisher
Sun X, Ritzenthaler J, Zheng Y, Roman J, Han S. Rosiglitazone inhibits alpha4 nicotinic acetylcholine receptor expression in human lung carcinoma cells through peroxisome proliferator-activated receptor gamma-independent signals. Mol Cancer Ther. 2009;8:110-8 pubmed publisher

product information

brand :

Tocris

catalog number base :

2737

SKU :

2737/10

product name :

TC 2559 difumarate

units size :

10 mg (also 50 mg)

description :

Selective 4 2 nAChR partial agonist

target :

Nicotinic (a4b2) Receptor Agonists

category :

Small Molecules

purity :

98%

observed molecular weight :

438.43

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

TC 2559 difumarate is a subtype-selective partial agonist for 4 2 nicotinic acetylcholine receptors (EC50 values are 0.18, 12.5, 14.0, 30, 100 and 100 u M for 4 2, 4 4, 2 4, 3 4, 3 2 and 7 receptor subtypes respectively). Displays selectivity for ( 4)2( 2)3 receptor stoichiometry and enhanced CNS-PNS selectivity ratio. Attenuates scopolamine-induced cognitive deficits in a step-through passive avoidance task.

top caption :

Selective 4 2 nAChR partial agonist

extended description :

Selective 4 2 nAChR partial agonist

chemical name text :

4-(5-ethoxy-3-pyridinyl)-N-methyl-(3E)-3-buten-1-amine difumarate

formula :

C12H18N2O.2C4H4O4

formula text :

C12H18N2O.2C4H4O4

cas num :

2454492-41-0

USD :

272 USD

product details :

Selective 4 2 nAChR partial agonist

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage