Sazetidine A dihydrochloride | Tocris Bioscience 2736 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Sazetidine A dihydrochloride

catalog :

2736

quantity :

10 mg

price :

214 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Kiguchi N, Kobayashi D, Saika F, Matsuzaki S, Kishioka S. Inhibition of peripheral macrophages by nicotinic acetylcholine receptor agonists suppresses spinal microglial activation and neuropathic pain in mice with peripheral nerve injury. J Neuroinflammation. 2018;15:96 pubmed publisher
Kutlu M, Tumolo J, Cann C, Gould T. Differential effects of α4β2 nicotinic receptor antagonists and partial-agonists on contextual fear extinction in male C57BL/6 mice. Psychopharmacology (Berl). 2018;235:1211-1219 pubmed publisher
Brown J, Wonnacott S. Sazetidine-A Activates and Desensitizes Native ?7 Nicotinic Acetylcholine Receptors. Neurochem Res. 2015;40:2047-54 pubmed publisher
Kuryatov A, Mukherjee J, Lindstrom J. Chemical chaperones exceed the chaperone effects of RIC-3 in promoting assembly of functional ?7 AChRs. PLoS ONE. 2013;8:e62246 pubmed publisher

product information

brand :

Tocris

master code :

2736

SKU :

2736/10

product name :

Sazetidine A dihydrochloride

description :

4 2 nAChR ligand; may act as an agonist or a desensitizer

target :

Additional Nicotinic (a4b2) Receptor Compounds

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

333.25

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Subtype-selective 4 2 nicotinic acetylcholine receptor ligand (Ki values are 0.26 and 54 nM at 4 2 and 3 4 receptors respectively). May act as a silent desensitizer or as an agonist, depending on subunit stoichiometry (EC50 = 1.1 nM for nAChR-stimulated dopamine release). Exhibits analgesic activity in vivo and significantly reduces nicotine self-administration in an experimental rat model.

catalog number base :

2736

extended description :

4 2 nAChR ligand; may act as an agonist or a desensitizer

chemical name text :

6-[5-[(2S)-2-Azetidinylmethoxy]-3-pyridinyl]-5-hexyn-1-ol dihydrochloride

formula :

C 15 H 20 N 2 O 2 .2HCl

formula text :

C15H20N2O2.2HCl

USD :

214 USD

storage :

Desiccate at +4°C

more info or order :

Tocris Bioscience product webpage