PNU 96415E | Tocris Bioscience 2735 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PNU 96415E

catalog :

2735

quantity :

10 mg (also 50 mg)

price :

155 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Dolma S, Selvadurai H, Lan X, Lee L, Kushida M, Voisin V, et al. Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells. Cancer Cell. 2016;29:859-873 pubmed publisher

product information

brand :

Tocris

master code :

2735

SKU :

2735/10

product name :

PNU 96415E

description :

D4 and 5-HT2A antagonist; antipsychotic

target :

Dopamine D4 Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

413.36

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Antipsychotic agent. Displays high affinity for dopamine D4 and serotonergic 5-HT2A receptors and relatively weak affinity at D2 receptors (Ki values are 3.0, 5.8, 134, 181, 199, 240, 411 and 678 nM for D4, 5-HT2A, 5-HT1A, 1, D2, D3, D1, 2 and muscarinic receptors respectively). Inhibits exploratory locomotor activity and antagonizes d-amphetamine-induced locomotor stimulation in rats.

catalog number base :

2735

extended description :

D4 and 5-HT2A antagonist; antipsychotic

chemical name text :

1-[2-(3,4-Dihydro-1H-2-benzopyran-1-yl)ethyl]-4-(4-fluorophenyl)piperazine dihydrochloride

formula :

C 21 H 25 FN 2 O.2HCl

formula text :

C21H25FN2O.2HCl

cas num :

170856-41-4

USD :

155 USD

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage