CGP 57380 | Tocris Bioscience 2731/10 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

CGP 57380

catalog :

2731/10

quantity :

10 mg

price :

237 USD

citations: 7

Reference
Brown M, Gromeier M. MNK Controls mTORC1:Substrate Association through Regulation of TELO2 Binding with mTORC1. Cell Rep. 2017;18:1444-1457 pubmed publisher
Riz I, Hawley T, Marsal J, Hawley R. Noncanonical SQSTM1/p62-Nrf2 pathway activation mediates proteasome inhibitor resistance in multiple myeloma cells via redox, metabolic and translational reprogramming. Oncotarget. 2016;7:66360-66385 pubmed publisher
Royall E, Doyle N, Abdul Wahab A, Emmott E, Morley S, Goodfellow I, et al. Murine norovirus 1 (MNV1) replication induces translational control of the host by regulating eIF4E activity during infection. J Biol Chem. 2015;290:4748-58 pubmed publisher
Brown M, Dobrikov M, Gromeier M. Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated translation and viral oncolysis. J Virol. 2014;88:13149-60 pubmed publisher
Dumoulin M, Aton S, Watson A, Renouard L, Coleman T, Frank M. Extracellular signal-regulated kinase (ERK) activity during sleep consolidates cortical plasticity in vivo. Cereb Cortex. 2015;25:507-15 pubmed publisher
Origanti S, Nowotarski S, Carr T, Sass Kuhn S, Xiao L, Wang J, et al. Ornithine decarboxylase mRNA is stabilized in an mTORC1-dependent manner in Ras-transformed cells. Biochem J. 2012;442:199-207 pubmed publisher
Melemedjian O, Asiedu M, Tillu D, Peebles K, Yan J, Ertz N, et al. IL-6- and NGF-induced rapid control of protein synthesis and nociceptive plasticity via convergent signaling to the eIF4F complex. J Neurosci. 2010;30:15113-23 pubmed publisher

product information

brand :

Tocris

master code :

2731

SKU :

2731/10

product name :

CGP 57380

description :

Selective inhibitor of Mnk1

target :

Other Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

244.23

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

CGP 57380 is an inhibitor of MAP-kinase interacting kinase-1 (Mnk1, MKNK1) (IC50 = 2.2 u M) that displays selectivity over p38, JNK1, ERK1, ERK2, PKC and c-src family kinases. Blocks phosphorylation of eIF4E in cellular assays (IC50 = 3 u M) and inhibits LPS-induced TNF expression in macrophages.

catalog number base :

2731

extended description :

Selective inhibitor of Mnk1

chemical name text :

N3-(4-Fluorophenyl)-1H-pyrazolo-[3,4-d]pyrimidine-3,4-diamine

formula :

C 11 H 9 FN 6

formula text :

C11H9FN6

cas num :

522629-08-9

USD 2021 :

227

USD 2022 :

237 USD

product details :

Selective inhibitor of Mnk1

storage :

Store at +4°C