ACET | Tocris Bioscience 2728/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

ACET

catalog :

2728/10

quantity :

10 mg

price :

501 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Kiyama T, Long Y, Chen C, Whitaker C, Shay A, Wu H, et al. Essential Roles of Tbr1 in the Formation and Maintenance of the Orientation-Selective J-RGCs and a Group of OFF-Sustained RGCs in Mouse. Cell Rep. 2019;27:900-915.e5 pubmed publisher
Ichinose T, Hellmer C. Differential signalling and glutamate receptor compositions in the OFF bipolar cell types in the mouse retina. J Physiol. 2016;594:883-94 pubmed publisher
Clarke V, Molchanova S, Hirvonen T, Taira T, Lauri S. Activity-dependent upregulation of presynaptic kainate receptors at immature CA3-CA1 synapses. J Neurosci. 2014;34:16902-16 pubmed publisher
Granger A, Nicoll R. LTD expression is independent of glutamate receptor subtype. Front Synaptic Neurosci. 2014;6:15 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2728

SKU :

2728/10

product name :

ACET

description :

Potent kainate antagonist; displays selectivity for GluK1-containing receptors

target :

Kainate Receptor Antagonists

unit size :

10 mg

category :

Small Molecules

purity :

98%

storage :

Store at RT

observed molecular weight :

429.45

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ACET is a potent and selective GluK1 (formerly GluR5) containing kainate receptor antagonist (IC50 = 7 nM) that displays selectivity over GluK2 (formerly GluR6) containing kainate, NMDA, AMPA and group I mGlu receptors. Reversibly blocks induction of NMDA receptor-independent long term potentiation (LTP) in vitro at nanomolar concentrations. . Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions .

product keywords :

Potent antagonists GluR5-containing kainate receptors Glutamate Kainate Receptors iGluR Ionotropic GluK1 Kainate Receptors 2728,

extended description :

Potent kainate antagonist; displays selectivity for GluK1-containing receptors

chemical name text :

(S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxy-5-phenylthiophene-3-yl-methyl)-5-methylpyrimidine-2,4-dione

formula :

C20H19N3O6S

formula text :

C20H19N3O6S

cas num :

936095-50-0

USD :

486

USD 2025 :

501 USD

product details :

Potent kainate antagonist; displays selectivity for GluK1-containing receptors

more info or order :

Tocris Bioscience product webpage